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著作: Mayila Yiliyasi/[松崎 利也]/[岩佐 武]/ALTANKHUU TUNGALAGSUVD/Munkhsaikhan Munkhzaya/矢野 清人/Yanagihara Rie/德井 貴子/[加藤 剛志]/[桑原 章]/[苛原 稔]/The reduction in sexual behavior induced by neonatal immune stress is not related to androgen levels in male rats./[International Journal of Developmental Neuroscience]

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EID
351789
EOID
968361
Map
0
LastModified
2019年12月14日(土) 14:28:36
Operator
岩佐 武
Avail
TRUE
Censor
0
Owner
苛原 稔
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種別 必須
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Mayila Yiliyasi / (日) Mayila Yiliyasi / (読) まいら いりやす
    役割 任意
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    学籍番号 推奨 ****
  2. 松崎 利也
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  3. 岩佐 武([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.産科婦人科学])
    役割 任意
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    学籍番号 推奨
  4. (英) Tungalagsuvd Altankhuu / (日) ALTANKHUU TUNGALAGSUVD / (読) あるたんふう つんがらぐすぶど
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    学籍番号 推奨 ****
  5. (英) Munkhzaya Munksaihan / (日) Munkhsaikhan Munkhzaya / (読) むんふさいはん むんふざや
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  6. (英) Yano Kiyohito / (日) 矢野 清人 / (読) やの きよひと
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  7. (英) Yanagihara Rie
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  8. (英) Tokui Takako / (日) 德井 貴子 / (読) とくい たかこ
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  9. 加藤 剛志([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.産科婦人科学])
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  10. 桑原 章
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  11. 苛原 稔([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.産科婦人科学])
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題名 必須

(英) The reduction in sexual behavior induced by neonatal immune stress is not related to androgen levels in male rats.

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要約 任意

(英) It is known that various types of stress in early life increase the incidence of diabetes, myocardial infarctions, and psychiatric disorders in adulthood. We examined the mechanism by which neonatal immune stress reduces sexual behavior in adult male rats. Male rats were randomly divided into 3 groups: the control (n = 17), postnatal day 10 lipopolysaccharide (PND10LPS) (n = 31), and PND25LPS (n = 16) groups, which received intraperitoneal injections of LPS (100 μg/kg) or saline (injection volume: 0.1 ml/g) on postnatal days 10 and 25. In experiment 1, male rats (age: 11 to 12 weeks) were put together with female rats in a one-to-one setting for mating, and sexual behavior (mounting, intromission, and ejaculation) was monitored for 30 minutes. The serum levels of luteinizing hormone (LH) and testosterone (T) and the hypothalamic mRNA expression levels of factors related to sexual behavior were examined. After experiment 1 finished, the remaining 37 male rats were used for experiment 2: the control group (n = 8), PND10 LPS group (n = 21) and PND25LPS group (n = 8) these rats had been given an i.p. injection of the saline during the expriment1. All of the rats were orchidectomized at 14 weeks of age. After a 3-week recovery period, a silastic tube containing crystalline T was subcutaneously implanted into the back of each rat. The rats' sexual behavior, serum hormone concentrations, and hypothalamic mRNA expression levels were assessed. In experiment 1, preputial separation occurred significantly later in the PND10LPS group than in the control group. The frequency of sexual behavior was significantly lower in the PND10LPS group than in the control group. The serum T concentrations of the PND10LPS and PND25LPS groups were significantly lower than that of the control group, but the serum LH concentrations of the 3 groups did not differ significantly. The hypothalamic mRNA expression levels of progesterone receptor B (PRB) and gonadotropin-releasing hormone (GnRH) were significantly lower in the PND10LPS and PND25LPS groups than in the control group, whereas the hypothalamic PRA + B mRNA expression levels of the 3 groups did not differ significantly. In experiment 2, after T supplementation the frequency of sexual behavior was significantly lower in the PND10LPS and PND25LPS groups than in the control group, although there were no significant differences in the serum T or LH concentrations or the hypothalamic PRB, PRA + B, or GnRH mRNA expression levels of the 3 groups. In male rats, immune stress in the early neonatal period delayed sexual maturation, reduced sexual behavior, suppressed the serum T concentration, and downregulated the hypothalamic mRNA expression levels of GnRH and the PR in adulthood. The delayed sexual maturation was presumed to have been caused by the reduction in the serum T concentration. However, the rats that experienced neonatal stress exhibited reduced sexual behavior irrespective of their serum T concentrations.

キーワード 推奨
  1. (英) Age Factors
  2. (英) Androgens
  3. (英) Animals
  4. (英) Animals, Newborn
  5. (英) Disorders of Sex Development
  6. (英) Gene Expression Regulation, Developmental
  7. (英) Gonadotropin-Releasing Hormone
  8. (英) Hypothalamus
  9. (英) Lipopolysaccharides
  10. (英) Luteinizing Hormone
  11. (英) Male
  12. (英) RNA, Messenger
  13. (英) Rats
  14. (英) Receptors, Progesterone
  15. (英) Stress, Psychological
  16. (英) Testosterone
発行所 推奨
誌名 必須 International Journal of Developmental Neuroscience(International Society for Developmental Neuroscience)
(pISSN: 0736-5748, eISSN: 1873-474X)
ISSN 任意 1873-474X
ISSN: 0736-5748 (pISSN: 0736-5748, eISSN: 1873-474X)
Title: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
Title(ISO): Int J Dev Neurosci
Supplier: International Society for Development Neuroscience
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 71
必須
必須 163 171
都市 任意
年月日 必須 2018年 8月 18日
URL 任意
DOI 任意 10.1016/j.ijdevneu.2018.08.003    (→Scopusで検索)
PMID 任意 30130567    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: S0736-5748(18)30115-1

  2. (英) Article.ELocationID: 10.1016/j.ijdevneu.2018.08.003

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) KeywordList.Keyword: Immune stress

  5. (英) KeywordList.Keyword: Lipopolysaccharide

  6. (英) KeywordList.Keyword: Progesterone receptor

  7. (英) KeywordList.Keyword: Sexual behavior

  8. (英) KeywordList.Keyword: Sexual maturation

  9. (英) KeywordList.Keyword: Testosterone