著作: Saito Yuko/[山田 博胤]/[楠瀬 賢也]/Saito Ken/[佐田 政隆]/Noninvasive assessment of left-ventricular diastolic electromechanical coupling in hypertensive heart disease,/[Journal of Echocardiography]/[佐田 政隆]
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種別 | 必須 | 学術論文(審査論文) | |||
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言語 | 必須 | 英語 | |||
招待 | 推奨 | ||||
審査 | 推奨 | Peer Review | |||
カテゴリ | 推奨 | 研究 | |||
共著種別 | 推奨 | 国内共著(徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない)) | |||
学究種別 | 推奨 | 博士課程学生による研究報告 | |||
組織 | 推奨 | ||||
著者 | 必須 | ||||
題名 | 必須 |
(英) Noninvasive assessment of left-ventricular diastolic electromechanical coupling in hypertensive heart disease, |
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副題 | 任意 | ||||
要約 | 任意 |
(英) There is a need to stratify patients who may develop heart failure because of the current "heart failure pandemic". We hypothesized that noninvasive assessment of diastolic electromechanical coupling by electrocardiography and Doppler echocardiography may be clinically useful for risk stratification of hypertensive patients who may develop heart failure. We measured the time from the peak to end of the T wave (TpTe) as an electrophysiological parameter, and peak early diastolic mitral flow (E) and lateral annular (e') velocities as mechanical parameters in 109 patients with hypertension. Relationships between these parameters and their association with the prognosis were evaluated. The e' was inversely correlated with TpTe (p < 0.001) and QTc (p < 0.014), whereas E/e' was positively correlated with TpTe (p < 0.001) and QTc (p < 0.001). The TpTe predicted patients with E/e' > 12. There were 24 cardiovascular events during follow-up (57 ± 20 months), and Kaplan-Meier analysis showed that outcome was worse (p = 0.003) in patients with higher E/e' than lower E/e'; however, there was no difference between patients with longer TpTe (≧72 ms) and shorter TpTe (< 72 ms). The correlation of TpTe with e' and E/e' in hypertensive patients suggests that these parameters reflect diastolic ventricular electromechanical coupling. The E/e' predicted outcome, and an elevated E/e' should be suspected when TpTe is prolonged (> 72 ms). Noninvasive evaluation of diastolic electromechanical coupling is clinically useful in patients with hypertension for predicting their outcome. |
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キーワード | 推奨 | ||||
発行所 | 推奨 | ||||
誌名 | 必須 |
Journal of Echocardiography(日本心エコー図学会)
(pISSN: 1349-0222, eISSN: 1880-344X)
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巻 | 必須 | 17 | |||
号 | 必須 | 4 | |||
頁 | 必須 | 206 212 | |||
都市 | 任意 | ||||
年月日 | 必須 | 2019年 2月 12日 | |||
URL | 任意 | ||||
DOI | 任意 | 10.1007/s12574-019-00421-4 (→Scopusで検索) | |||
PMID | 任意 | 30756346 (→Scopusで検索) | |||
CRID | 任意 | ||||
WOS | 任意 | ||||
Scopus | 任意 | 2-s2.0-85061449967 | |||
評価値 | 任意 | ||||
被引用数 | 任意 | ||||
指導教員 | 推奨 |
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備考 | 任意 |
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