350356: [和泉唯信]/[宮本亮介]/[藤田浩司]/Yamamoto Yuki/[山田博胤]/Matsubara Tomoyasu/Unai Yuki/Tsukamoto Ai/Takamatsu Naoko/[野寺裕之]/Hayashi Shinya/Oda Masaya/Mori Atsuko/Nishida Yoshihiko/Watanabe Shunsuke/[小川博久]/[上原久典]/Murayama Shigeo/[佐田政隆]/[梶龍兒]/Distinct Incidence of Takotsubo Syndrome Between Amyotrophic Lateral Sclerosis and Synucleinopathies: A Cohort Study./[Frontiers in Neurology]

著作: [和泉唯信]/[宮本亮介]/[藤田浩司]/Yamamoto Yuki/[山田博胤]/Matsubara Tomoyasu/Unai Yuki/Tsukamoto Ai/Takamatsu Naoko/[野寺裕之]/Hayashi Shinya/Oda Masaya/Mori Atsuko/Nishida Yoshihiko/Watanabe Shunsuke/[小川博久]/[上原久典]/Murayama Shigeo/[佐田政隆]/[梶龍兒]/Distinct Incidence of Takotsubo Syndrome Between Amyotrophic Lateral Sclerosis and Synucleinopathies: A Cohort Study./[Frontiers in Neurology]

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EID: 350356
EOID: 968395
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LastModified: 2019年12月16日(月) 11:41:02
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種別

必須

学術論文(審査論文)

言語

必須

英語

招待

推奨

審査

推奨

Peer Review

カテゴリ

推奨

研究

共著種別

推奨

国内共著(徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))

学究種別

推奨

組織

推奨

著者

必須

和泉唯信([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.臨床神経科学]/[徳島大学.病院.診療科.内科.脳神経内科])

役割任意

貢献度任意

学籍番号推奨
宮本亮介([徳島大学.病院.診療科.内科.脳神経内科])

役割任意

貢献度任意

学籍番号推奨
藤田浩司([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.臨床神経科学]/[徳島大学.病院.診療科.内科.脳神経内科])

役割任意

貢献度任意

学籍番号推奨
(英) Yamamoto Yuki

役割任意

貢献度任意

学籍番号推奨
山田博胤

役割任意

貢献度任意

学籍番号推奨
(英) Matsubara Tomoyasu

役割任意

貢献度任意

学籍番号推奨
(英) Unai Yuki

役割任意

貢献度任意

学籍番号推奨
(英) Tsukamoto Ai

役割任意

貢献度任意

学籍番号推奨
(英) Takamatsu Naoko

役割任意

貢献度任意

学籍番号推奨
野寺裕之

役割任意

貢献度任意

学籍番号推奨
(英) Hayashi Shinya

役割任意

貢献度任意

学籍番号推奨
(英) Oda Masaya

役割任意

貢献度任意

学籍番号推奨
(英) Mori Atsuko

役割任意

貢献度任意

学籍番号推奨
(英) Nishida Yoshihiko

役割任意

貢献度任意

学籍番号推奨
(英) Watanabe Shunsuke

役割任意

貢献度任意

学籍番号推奨
小川博久([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.疾患病理学])

役割任意

貢献度任意

学籍番号推奨
上原久典([徳島大学.病院.中央診療施設等.病理部])

役割任意

貢献度任意

学籍番号推奨
(英) Murayama Shigeo

役割任意

貢献度任意

学籍番号推奨
佐田政隆([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])

役割任意

貢献度任意

学籍番号推奨
梶龍兒([徳島大学.研究支援・産官学連携センター])

役割任意

貢献度任意

学籍番号推奨

題名

必須

(英) Distinct Incidence of Takotsubo Syndrome Between Amyotrophic Lateral Sclerosis and Synucleinopathies: A Cohort Study.

副題

任意

要約

任意

(英) Takotsubo syndrome (TTS) is an acute cardiac syndrome characterized by regional left ventricular dysfunction with a peculiar circumferential pattern, which typically results in apical ballooning. Evidence indicates a pivotal role of catecholamines in TTS, and researchers have discussed multiple hypotheses on the etiology, including multivessel coronary spasm, myocardial stunning, excessive transient ventricular afterload, and cardiac sympathetic overactivity with local noradrenaline spillover. Although central nervous system disorders, such as stroke and epilepsy, are known to trigger TTS, the incidence and clinical features of TTS in neurodegenerative disorders are poorly understood. Here, we retrospectively examined TTS cases in a single-center cohort composed of 250 patients with amyotrophic lateral sclerosis (ALS) and 870 patients with synucleinopathies [582 patients with Parkinson's disease (PD), 125 patients with dementia with Lewy bodies (DLB), and 163 patients with multiple system atrophy (MSA)] and identified 4 (1.6%, including 2 women) cases with ALS and no cases with synucleinopathies. Two ALS patients underwent autopsy and the pathological findings were compatible with the chronological changes identified in catecholamine-induced cardiomyopathy. A literature review identified 16 TTS cases with ALS, 1 case each with PD and DLB, and no cases with MSA. When current and previous TTS cases with ALS were concatenated: 55% (11/20) were female; 35% (7/20) had a bulbar-onset and 45% (9/20) had a limb-onset; the mean age of TTS onset was 63.3 ± 9.0 years and the mean interval time from ALS onset to TTS development was 4.9 ± 3.0 years; no (0/16) patients developed TTS within 12 months after ALS onset; 50% (10/20) underwent artificial ventilations; the mortality was 17% (3/18); and most cases had precipitating factors, and TTS development was associated with gastrostomy, tracheostomy, or infections in 45% (9/20) of the patients. This study demonstrated that ALS is a considerable predisposing factor of TTS and that synucleinopathies rarely cause TTS. The distinct TTS incidence between ALS and synucleinopathies may be due to cardiac sympathetic overactivity in ALS and may also be affected by cardiac sympathetic denervation in synucleinopathies. Moreover, the etiology of TTS in ALS may be reasonably explained by the two-hit theory.

キーワード

推奨

発行所

推奨

誌名

必須

Frontiers in Neurology(Frontiers Media S.A.)

(eISSN: 1664-2295)

ISSN	任意	1664-2295 ISSN: 1664-2295 (eISSN: 1664-2295) Title: Frontiers in neurology Title(ISO): Front Neurol Publisher: Frontiers Media S.A. (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

必須

号

必須

---

頁

必須

1099 1099

都市

任意

年月日

必須

2018年 12月 13日

URL

任意

DOI

任意

10.3389/fneur.2018.01099 (→Scopusで検索)

PMID

任意

30619056 (→Scopusで検索)

CRID

任意

WOS

任意

Scopus

任意

評価値

任意

被引用数

任意

指導教員

推奨

備考

任意

(英) Article.ELocationID: 10.3389/fneur.2018.01099
(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) KeywordList.Keyword: Parkinson's disease
(英) KeywordList.Keyword: amyotrophic lateral sclerosis
(英) KeywordList.Keyword: dementia with Lewy bodies
(英) KeywordList.Keyword: multiple system atrophy
(英) KeywordList.Keyword: noradrenaline
(英) KeywordList.Keyword: sympathetic nerve
(英) KeywordList.Keyword: synucleinopathy
(英) KeywordList.Keyword: takotsubo syndrome

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