徳島大学 教育・研究者情報データベース(EDB)

1. 福田 直志([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔外科学])

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2. (英) Ishikawa Kunio / (日) 石川 邦夫

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3. (英) Akita Kazuya / (日) 秋田 和也 / (読) あきた かずや

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4. (英) Kamada Kumiko / (日) 鎌田 久美子 / (読) かまだ くみこ

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5. 栗尾 奈愛([徳島大学.病院.診療科.歯科口腔外科.口腔外科])

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6. (英) Mori Yoshihide

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7. 宮本 洋二

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(英) Effects of acidic calcium phosphate concentration on setting reaction and tissue response to β-tricalcium phosphate granular cement.

(英) Beta-tricalcium phosphate granular cement (β-TCP GC), consisting of β-TCP granules and an acidic calcium phosphate (Ca-P) solution, shows promise in the reconstruction of bone defects as it sets to form interconnected porous structures, that is, β-TCP granules are bridged with dicalcium phosphate dihydrate (DCPD) crystals. In this study, the effects of acidic Ca-P solution concentration (0-600 mmol/L) on the setting reaction and tissue response to β-TCP GC were investigated. The β-TCP GC set upon mixing with its liquid phase, based on the formation of DCPD crystals, which bridged β-TCP granules to one another. Diametral tensile strength of the set β-TCP GC was relatively the same, at ∼0.6 MPa, when the Ca-P concentration was 20-600 mmol/L. Due to the setting ability, reconstruction of the rat's calvarial bone defect using β-TCP GC with 20, 200, and 600 mmol/L Ca-P solution was much easier compared to that with β-TCP granules without setting ability. Four weeks after the reconstruction, the amount of new bone was the same, ∼17% in both β-TCP GC and β-TCP granules groups. Cellular response to β-TCP granules and β-TCP GC using the 20 mmol/L acidic Ca-P solution was almost the same. However, β-TCP GC using the 200 and 600 mmol/L acidic Ca-P solution showed a more severe inflammatory reaction. It is concluded, therefore, that β-TCP GC, using the 20 mmol/L acidic Ca-P solution, is recommended as this concentration allows surgical techniques to be performed easily and provides good mechanical strength, and the similar cellular response to β-TCP granules. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B, 2019.

1. (英) Article.ELocationID: 10.1002/jbm.b.34361

2. (英) Article.PublicationTypeList.PublicationType: Journal Article

3. (英) KeywordList.Keyword: dicalcium phosphate dihydrate

4. (英) KeywordList.Keyword: granular cement

5. (英) KeywordList.Keyword: self-setting

6. (英) KeywordList.Keyword: β-tricalcium phosphate