著作: 石川 邦夫/[宮本 洋二]/土谷 享/林 幸壱朗/都留 寛治/[大江 剛]/Physical and Histological Comparison of Hydroxyapatite, Carbonate Apatite, and -Tricalcium Phosphate Bone Substitutes./[Materials]
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種別 | 必須 | 学術論文(紀要その他) | |||
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言語 | 必須 | 英語 | |||
招待 | 推奨 | ||||
審査 | 推奨 | ||||
カテゴリ | 推奨 | ||||
共著種別 | 推奨 | 国内共著(徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない)) | |||
学究種別 | 推奨 | ||||
組織 | 推奨 | ||||
著者 | 必須 | ||||
題名 | 必須 |
(英) Physical and Histological Comparison of Hydroxyapatite, Carbonate Apatite, and -Tricalcium Phosphate Bone Substitutes. |
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副題 | 任意 | ||||
要約 | 任意 |
(英) Three commercially available artificial bone substitutes with different compositions, hydroxyapatite (HAp; Neobone), carbonate apatite (CO3Ap; Cytrans), and β-tricalcium phosphate (β-TCP; Cerasorb), were compared with respect to their physical properties and tissue response to bone, using hybrid dogs. Both Neobone (HAp) and Cerasorb (β-TCP) were porous, whereas Cytrans (CO3Ap) was dense. Crystallite size and specific surface area (SSA) of Neobone (HAp), Cytrans (CO3Ap), and Cerasorb (β-TCP) were 75.4 ± 0.9 nm, 30.8 ± 0.8 nm, and 78.5 ± 7.5 nm, and 0.06 m²/g, 18.2 m²/g, and 1.0 m²/g, respectively. These values are consistent with the fact that both Neobone (HAp) and Cerasorb (β-TCP) are sintered ceramics, whereas Cytrans (CO3Ap) is fabricated in aqueous solution. Dissolution in pH 5.3 solution mimicking Howship's lacunae was fastest in CO3Ap (Cytrans), whereas dissolution in pH 7.3 physiological solution was fastest in β-TCP (Cerasorb). These results indicated that CO3Ap is stable under physiological conditions and is resorbed at Howship's lacunae. Histological evaluation using hybrid dog mandible bone defect model revealed that new bone was formed from existing bone to the center of the bone defect when reconstructed with CO3Ap (Cytrans) at week 4. The amount of bone increased at week 12, and resorption of the CO3Ap (Cytrans) was confirmed. β-TCP (Cerasorb) showed limited bone formation at week 4. However, a larger amount of bone was observed at week 12. Among these three bone substitutes, CO3Ap (Cytrans) demonstrated the highest level of new bone formation. These results indicate the possibility that bone substitutes with compositions similar to that of bone may have properties similar to those of bone. |
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キーワード | 推奨 | ||||
発行所 | 推奨 | ||||
誌名 | 必須 |
Materials(Molecular Diversity Preservation International/Multidisciplinary Digital Publishing Institute)
(eISSN: 1996-1944)
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巻 | 必須 | 11 | |||
号 | 必須 | 10 | |||
頁 | 必須 | --- | |||
都市 | 任意 | ||||
年月日 | 必須 | 2018年 10月 16日 | |||
URL | 任意 | ||||
DOI | 任意 | 10.3390/ma11101993 (→Scopusで検索) | |||
PMID | 任意 | 30332751 (→Scopusで検索) | |||
CRID | 任意 | ||||
WOS | 任意 | ||||
Scopus | 任意 | 2-s2.0-85054990038 | |||
評価値 | 任意 | ||||
被引用数 | 任意 | ||||
指導教員 | 推奨 | ||||
備考 | 任意 |
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