徳島大学 教育・研究者情報データベース(EDB)

1. (英) Yamanomoto Ken / (日) 山野本 健 / (読) やまのもと けん

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2. (英) Kita Hazuki / (日) 喜多 葉月 / (読) きた はづき

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3. 荒川 幸弘([徳島大学.大学院社会産業理工学研究部.理工学域.応用化学系.物質合成化学分野]/[徳島大学.理工学部.理工学科.応用化学システムコース.物質合成化学講座])

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4. 南川 慶二([徳島大学.教養教育院])

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5. 今田 泰嗣

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(英) Enzyme-like Regiodivergent Behavior of a Flavopeptide Catalyst in Aerobic Baeyer-Villiger Oxidation

(英) We recently developed a flavopeptide immobilized on polystyrene resin, , that could realize the first 5-unmodified neutral flavin ()-catalyzed aerobic oxygenation reactions under non-enzymatic conditions. Although a key active species is assumed to be the corresponding 4a-hydroperoxyflavin () from the unprecedented activity and unique chemoselectivity, further circumstantial support would be helpful to be sure since spectroscopic evidence is difficult to obtain due to the compound's insolubility. In this article, we report that the aerobic Baeyer-Villiger oxidation of a fused cyclobutanone, (±)--bicyclo[3.2.0]hept-2-en-6-one (), can be promoted with in a FMO-like chemoselectivity and regiodivergent manner -related catalytic intermediates, which delivers strong evidence of the involvement of as an active species in -catalyzed aerobic oxygenation reactions.

1. (英) Butanones
2. (英) Catalysis
3. (英) Models, Molecular
4. (英) Molecular Structure
5. (英) Oxidation-Reduction
6. (英) Peptides

1. (英) Article.ELocationID: 10.2533/chimia.2018.866

2. (英) Article.PublicationTypeList.PublicationType: Journal Article