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著作: [河合 慶親]/額 惠理香/Abundance of DNA adducts of 4-oxo-2-alkenals, lipid peroxidation-derived highly reactive genotoxins/[Journal of Clinical Biochemistry and Nutrition]

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2018年9月18日(火) 20:10:15
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大家 隆弘
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河合 慶親
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種別 必須 総説·解説
言語 必須 英語
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  1. 河合 慶親
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  2. (英) Erika Nuka / (日) 額 惠理香 / (読) ぬか えりか
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    貢献度 任意
    学籍番号 推奨 ****
題名 必須

(英) Abundance of DNA adducts of 4-oxo-2-alkenals, lipid peroxidation-derived highly reactive genotoxins

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(英) Reactive oxygen species and their reaction products can damage DNA to form mutagenic lesions. Among the reactive species, lipid peroxidation-derived aldehydes react with nucleobases and form bulky exocyclic adducts. Many types of aldehyde-derived DNA adducts have been characterized, identified and detected and , whereas relative quantitative and pathophysiological contributions of each adduct still remain unclear. In recent years, an abundant class of DNA adducts derived from 4-oxo-2-alkenals have been identified, in addition to classic aldehyde-derived adducts. The presence of 4-oxo-2-alkenal-derived DNA adducts associated with age-related diseases has been revealed in rodents and humans. studies have demonstrated that 4-oxo-2-alkenals, as compared with other classes of lipid peroxidation-derived aldehydes, are highly reactive with nucleobases. It has been generally recognized that 4-oxo-2-alkenals are generated through oxidative degradation of the corresponding 4-hydroperoxy-2-alkenals, homolytic degradation products of polyunsaturated fatty acid hydroperoxides. Our recent results have also shown an alternative pathway for the formation of 4-oxo-2-alkenals, in which 2-alkenals could undergo the metal-catalyzed autoxidation resulting in the formation of the corresponding 4-oxo-2-alkenals. This review summarizes the basis of the formation of lipid peroxidation-derived genotoxic aldehydes and their covalent adduction to nucleobases, especially focusing on the abundance of 4-oxo-2-alkenal-derived DNA adducts.

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誌名 必須 Journal of Clinical Biochemistry and Nutrition(日本酸化ストレス学会)
(pISSN: 0912-0009, eISSN: 1880-5086)
ISSN 任意 0912-0009
ISSN: 0912-0009 (pISSN: 0912-0009, eISSN: 1880-5086)
Title: Journal of clinical biochemistry and nutrition
Title(ISO): J Clin Biochem Nutr
Supplier: 一般社団法人 日本酸化ストレス学会
Publisher: Institute of Applied Biochemistry
 (NLM Catalog  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 62
必須 1
必須 3 10
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年月日 必須 2017年 12月 12日
URL 任意
DOI 任意 10.3164/jcbn.17-90    (→Scopusで検索)
PMID 任意 29362517    (→Scopusで検索)
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  1. (英) Article.ELocationID: 10.3164/jcbn.17-90

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Review

  4. (英) KeywordList.Keyword: 4-oxo-2-alkenal

  5. (英) KeywordList.Keyword: DNA adduct

  6. (英) KeywordList.Keyword: aldehyde

  7. (英) KeywordList.Keyword: lipid peroxidation

  8. (英) CoiStatement: No potential conflicts of interest were disclosed.