著作: [西田 憲生]/[桑野 由紀]/[西川 達哉]/[増田 清士]/[六反 一仁]/RNA Binding Proteins and Genome Integrity./[International Journal of Molecular Sciences]
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種別 | 必須 | 総説·解説 | |||
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言語 | 必須 | 英語 | |||
招待 | 推奨 | ||||
審査 | 推奨 | Peer Review | |||
カテゴリ | 推奨 | ||||
共著種別 | 推奨 | ||||
学究種別 | 推奨 | ||||
組織 | 推奨 | ||||
著者 | 必須 | ||||
題名 | 必須 |
(英) RNA Binding Proteins and Genome Integrity. |
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副題 | 任意 | ||||
要約 | 任意 |
(英) Genome integrity can be threatened by various endogenous or exogenous events. To counteract these stressors, the DNA damage response network contributes to the prevention and/or repair of genomic DNA damage and serves an essential function in cellular survival. DNA binding proteins are involved in this network. Recently, several RNA-binding proteins (RBPs) that are recruited to DNA damage sites have been shown to be direct players in the prevention or repair of DNA damage. In addition, non-coding RNAs, themselves, are involved in the RNA-mediated DNA repair system. Furthermore, RNA modification such as m6A methylation might also contribute to the ultraviolet-responsive DNA damage response. Accumulating evidence suggests that RNA metabolism is more deeply involved in diverse cellular functions than previously expected, and is also intricately associated with the maintenance of genome integrity. In this review, we highlight the roles of RBPs in the maintenance of genome integrity. |
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キーワード | 推奨 |
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発行所 | 推奨 | ||||
誌名 | 必須 |
International Journal of Molecular Sciences(Molecular Diversity Preservation International/Multidisciplinary Digital Publishing Institute)
(pISSN: 1661-6596, eISSN: 1422-0067)
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巻 | 必須 | 18 | |||
号 | 必須 | 7 | |||
頁 | 必須 | ||||
都市 | 任意 | ||||
年月日 | 必須 | 2017年 6月 23日 | |||
URL | 任意 | ||||
DOI | 任意 | 10.3390/ijms18071341 (→Scopusで検索) | |||
PMID | 任意 | 28644387 (→Scopusで検索) | |||
CRID | 任意 | ||||
WOS | 任意 | ||||
Scopus | 任意 | ||||
機関リポジトリ | 112411 | ||||
評価値 | 任意 | ||||
被引用数 | 任意 | ||||
指導教員 | 推奨 | ||||
備考 | 任意 |
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