徳島大学 教育・研究者情報データベース(EDB)

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著作: Dondoo Tsogt-Ochir/[福森 知治]/Daizumoto Kei/[布川 朋也]/Kohzuki Miho/Kowada Minoru/[楠原 義人]/[森 英恭]/[中逵 弘能]/[高橋 正幸]/[金山 博臣]/Galectin-3 Is Implicated in Tumor Progression and Resistance to Anti-androgen Drug Through Regulation of Androgen Receptor Signaling in Prostate Cancer./[Anticancer Research]

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EID
343696
EOID
923356
Map
0
LastModified
2018年8月27日(月) 20:23:10
Operator
大家 隆弘
Avail
TRUE
Censor
0
Owner
福森 知治
Read
継承
Write
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継承
種別 必須
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Dondoo Tsogt-Ochir
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 福森 知治
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Daizumoto Kei
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 布川 朋也([徳島大学.病院.診療科.外科.泌尿器科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Kohzuki Miho
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Kowada Minoru
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. 楠原 義人([徳島大学.病院.診療科.外科.泌尿器科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. 森 英恭
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. 中逵 弘能
    役割 任意
    貢献度 任意
    学籍番号 推奨
  10. 高橋 正幸([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.泌尿器科学]/[徳島大学.病院.診療科.外科.泌尿器科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  11. 金山 博臣([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.泌尿器科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Galectin-3 Is Implicated in Tumor Progression and Resistance to Anti-androgen Drug Through Regulation of Androgen Receptor Signaling in Prostate Cancer.

副題 任意
要約 任意

(英) Castration-resistant prostate cancer (CRPC)-related deaths are increasing worldwide. Therefore, clarification of the mechanisms of hormone-related tumor progression and resistance to anti-androgen drugs is useful in order to develop strategies for appropriate treatment of CRPC. Galectin-3 has been shown to be correlated with tumor progression in a variety of cancer types through the regulation of tumor proliferation, angiogenesis, and apoptosis. We examined tumor cell invasion and migration using the xCELLigence system. Control LNCaP and galectin-3-expressing LNCaP (LNCaP-Gal-3) cells were cultured with androgen-depleted medium with 5% charcoal-stripped serum. Cells were treated for 24 h with or without dihydrotestosterone alone or combined with MDV3100 and bicalutamide; gene profile was then analyzed by microarray analysis and mRNA expression was confirmed by quantitative real-time polymerase chain reaction (qRT-PCR). We evaluated tumor growth using spheroids and xenograft tumor growth in a mouse model. In vitro, LNCaP-Gal-3 cells promoted both cell migration and invasion in an androgen-independent manner compared to control LNCaP cells. Galectin-3 also enhanced anchorage-independent growth and xenograft tumor growth even after castration. Importantly, galectin-3 greatly enhanced transcriptional activity of the androgen receptor (AR), especially on treatment with dihydrotestosterone. In microarray and qRT-PCR analyses, galectin-3 increased the expression of several AR-target genes, such as kallikrein-related peptidase 3 (KLK3), and transmembrane protease, serine 2 (TMPRSS2). These AR-target genes were not fully suppressed by anti-androgen drugs such as bicalutamide or MDV3100. Galectin-3 significantly inhibited the effect induced by anti-androgen drugs MDV3100 and bicalutamide, suggesting that galectin-3 may be involved in resistance to anti-androgen drug through enhancement of transcriptional activity of AR and expression of AR-related genes. These results suggest that galectin-3 is a potential target molecule for future treatment of anti-androgen drug-resistant prostate cancer.

キーワード 推奨
  1. (英) Androgen Antagonists
  2. (英) Anilides
  3. (英) Animals
  4. (英) Antineoplastic Agents, Hormonal
  5. (英) Cell Line, Tumor
  6. (英) Cell Movement
  7. (英) Cell Proliferation
  8. (英) Disease Progression
  9. (英) Drug Resistance, Neoplasm
  10. (英) Galectin 3
  11. (英) Gene Expression Profiling
  12. (英) Gene Expression Regulation, Neoplastic
  13. (英) Humans
  14. (英) Male
  15. (英) Mice, Inbred BALB C
  16. (英) Mice, Nude
  17. (英) Neoplasm Invasiveness
  18. (英) Nitriles
  19. (英) Oligonucleotide Array Sequence Analysis
  20. (英) Phenylthiohydantoin
  21. (英) Prostatic Neoplasms, Castration-Resistant
  22. (英) Real-Time Polymerase Chain Reaction
  23. (英) Receptors, Androgen
  24. (英) Signal Transduction
  25. (英) Tosyl Compounds
  26. (英) Transcription, Genetic
  27. (英) Xenograft Model Antitumor Assays
発行所 推奨
誌名 必須 Anticancer Research(International Institute of Anticancer Research(IIAR))
(pISSN: 0250-7005, eISSN: 1791-7530)
ISSN 任意 1791-7530
ISSN: 0250-7005 (pISSN: 0250-7005, eISSN: 1791-7530)
Title: Anticancer research
Title(ISO): Anticancer Res
Publisher: International Institute of Anticancer Research
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 37
必須 1
必須 125 134
都市 任意
年月日 必須 2017年 1月 初日
URL 任意
DOI 任意 10.21873/anticanres.11297    (→Scopusで検索)
PMID 任意 28011482    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.PublicationTypeList.PublicationType: Journal Article

  2. (英) KeywordList.Keyword: Prostate cancer

  3. (英) KeywordList.Keyword: anti-androgen resistance

  4. (英) KeywordList.Keyword: galectin-3 gene