343158: Takase Naoko/Inden Masatoshi/Sekine Shin-Ichiro/Ishii Yumi/Yonemitsu Hiroko/Iwashita Wakana/Kurita Hisaka/[竹谷豊]/Hozumi Isao/Neuroprotective effect of 5-aminolevulinic acid against low inorganic phosphate in neuroblastoma SH-SY5Y cells./[Scientific Reports]

著作: Takase Naoko/Inden Masatoshi/Sekine Shin-Ichiro/Ishii Yumi/Yonemitsu Hiroko/Iwashita Wakana/Kurita Hisaka/[竹谷豊]/Hozumi Isao/Neuroprotective effect of 5-aminolevulinic acid against low inorganic phosphate in neuroblastoma SH-SY5Y cells./[Scientific Reports]

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EID: 343158
EOID: 933096
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種別

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学術論文(審査論文)

言語

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英語

招待

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審査

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カテゴリ

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共著種別

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学究種別

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組織

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著者

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(英) Takase Naoko

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学籍番号推奨
(英) Inden Masatoshi

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貢献度任意

学籍番号推奨
(英) Sekine Shin-Ichiro

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貢献度任意

学籍番号推奨
(英) Ishii Yumi

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貢献度任意

学籍番号推奨
(英) Yonemitsu Hiroko

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貢献度任意

学籍番号推奨
(英) Iwashita Wakana

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学籍番号推奨
(英) Kurita Hisaka

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学籍番号推奨
竹谷豊([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.臨床食管理学])

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(英) Hozumi Isao

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(英) Neuroprotective effect of 5-aminolevulinic acid against low inorganic phosphate in neuroblastoma SH-SY5Y cells.

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(英) PiT-1 (encoded by SLC20A1) and PiT-2 (encoded by SLC20A2) are type-III sodium-dependent phosphate cotransporters (NaPiTs). Recently, SLC20A2 mutations have been found in patients with idiopathic basal ganglia calcification (IBGC), and were predicted to bring about an inability to transport Pi from the extracellular environment. Here we investigated the effect of low Pi loading on the human neuroblastoma SH-SY5Y and the human glioblastoma A172 cell lines. The results show a different sensitivity to low Pi loading and differential regulation of type-III NaPiTs in these cells. We also examined whether 5-aminolevulinic acid (5-ALA) inhibited low Pi loading-induced neurotoxicity in SH-SY5Y cells. Concomitant application of 5-ALA with low Pi loading markedly attenuated low Pi-induced cell death and mitochondrial dysfunction via the induction of HO-1 by p38 MAPK. The findings provide us with novel viewpoints to understand the pathophysiology of IBGC, and give a new insight into the clinical prevention and treatment of IBGC.

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Scientific Reports([Nature Publishing Group])

(eISSN: 2045-2322)

ISSN	任意	2045-2322 ISSN: 2045-2322 (eISSN: 2045-2322) Title: Scientific reports Title(ISO): Sci Rep Publisher: Nature Portfolio (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

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号

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年月日

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2017年 7月 18日

URL

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DOI

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10.1038/s41598-017-06406-6 (→Scopusで検索)

PMID

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28720798 (→Scopusで検索)

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Scopus

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機関リポジトリ

112434

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備考

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(英) PublicationType: Journal Article

徳島大学教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

著作: Takase Naoko/Inden Masatoshi/Sekine Shin-Ichiro/Ishii Yumi/Yonemitsu Hiroko/Iwashita Wakana/Kurita Hisaka/[竹谷豊]/Hozumi Isao/Neuroprotective effect of 5-aminolevulinic acid against low inorganic phosphate in neuroblastoma SH-SY5Y cells./[Scientific Reports]

著作: Takase Naoko/Inden Masatoshi/Sekine Shin-Ichiro/Ishii Yumi/Yonemitsu Hiroko/Iwashita Wakana/Kurita Hisaka/[竹谷 豊]/Hozumi Isao/Neuroprotective effect of 5-aminolevulinic acid against low inorganic phosphate in neuroblastoma SH-SY5Y cells./[Scientific Reports]

著作: Takase Naoko/Inden Masatoshi/Sekine Shin-Ichiro/Ishii Yumi/Yonemitsu Hiroko/Iwashita Wakana/Kurita Hisaka/[竹谷豊]/Hozumi Isao/Neuroprotective effect of 5-aminolevulinic acid against low inorganic phosphate in neuroblastoma SH-SY5Y cells./[Scientific Reports]