著作: [佐光 亘]/Murakami Nagahisa/Motohama Keisuke/Izumi Yuishin/Kaji Ryuji/The effect of istradefylline for Parkinson's disease: A meta-analysis./[Scientific Reports]
(英) The effect of istradefylline for Parkinson's disease: A meta-analysis.
(英) Adenosine A receptor antagonists are an alternative treatment strategy for Parkinson's disease. Several randomized placebo controlled studies have tested the effect of A receptor antagonist istradefylline, and more robust evidence has been acquired. This meta-analysis aimed to provide evidence for its efficacy and safety on patients with Parkinson's disease. After a systematic literature search, we calculated the pooled standardized mean difference and risk ratio for continuous and dichotomous variables, respectively. Further, sensitivity analyses were performed to confirm the effect estimated by meta-analyses. Publication bias was assessed by funnel plot and deviation of intercept. Six studies satisfied our inclusion criteria. Istradefylline (40g/day) decreased off time and improved motor symptoms of Parkinson's disease in homogeneous studies. Istradefylline at 20g/day decreased off time and improved motor symptoms, but heterogeneity was found in the analysis of the former among studies. There was a significant effect of istradefylline on dyskinesia in homogeneous studies. Publication bias, however, was observed in the comparison of dyskinesia. Other adverse events showed no significant difference. The present meta-analysis suggests that istradefylline at 40g/day could alleviate off time and motor symptoms derived from Parkinson's disease. Dyskinesia might be worsened, but publication bias prevents this from being clear.
Scientific Reports([Nature Publishing Group])
|年月日||必須||2017年 12月 21日|