徳島大学 教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

徳島大学ウェブサイトへのリンク

著作: [佐光 亘]/Murakami Nagahisa/Motohama Keisuke/Izumi Yuishin/Kaji Ryuji/The effect of istradefylline for Parkinson's disease: A meta-analysis./[Scientific Reports]

ヘルプを読む

「著作」(著作(著書,論文,レター,国際会議など))は,研究業績にかかる著作(著書,論文,レター,国際会議など)を登録するテーブルです. (この情報が属するテーブルの詳細な定義を見る)

  • 項目名の部分にマウスカーソルを置いて少し待つと,項目の簡単な説明がツールチップ表示されます.

この情報をEDB閲覧画面で開く

EID
342724
EOID
919332
Map
0
LastModified
2018年8月13日(月) 15:55:41
Operator
大家 隆弘
Avail
TRUE
Censor
0
Owner
佐光 亘
Read
継承
Write
継承
Delete
継承
種別 必須
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 佐光 亘
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Murakami Nagahisa
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Motohama Keisuke
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Izumi Yuishin
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Kaji Ryuji
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) The effect of istradefylline for Parkinson's disease: A meta-analysis.

副題 任意
要約 任意

(英) Adenosine A receptor antagonists are an alternative treatment strategy for Parkinson's disease. Several randomized placebo controlled studies have tested the effect of A receptor antagonist istradefylline, and more robust evidence has been acquired. This meta-analysis aimed to provide evidence for its efficacy and safety on patients with Parkinson's disease. After a systematic literature search, we calculated the pooled standardized mean difference and risk ratio for continuous and dichotomous variables, respectively. Further, sensitivity analyses were performed to confirm the effect estimated by meta-analyses. Publication bias was assessed by funnel plot and deviation of intercept. Six studies satisfied our inclusion criteria. Istradefylline (40g/day) decreased off time and improved motor symptoms of Parkinson's disease in homogeneous studies. Istradefylline at 20g/day decreased off time and improved motor symptoms, but heterogeneity was found in the analysis of the former among studies. There was a significant effect of istradefylline on dyskinesia in homogeneous studies. Publication bias, however, was observed in the comparison of dyskinesia. Other adverse events showed no significant difference. The present meta-analysis suggests that istradefylline at 40g/day could alleviate off time and motor symptoms derived from Parkinson's disease. Dyskinesia might be worsened, but publication bias prevents this from being clear.

キーワード 推奨
発行所 推奨
誌名 必須 Scientific Reports([Nature Publishing Group])
(eISSN: 2045-2322)
ISSN 任意 2045-2322
ISSN: 2045-2322 (eISSN: 2045-2322)
Title: Scientific reports
Title(ISO): Sci Rep
Publisher: Nature Portfolio
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 7
必須 1
必須 18018 18018
都市 任意
年月日 必須 2017年 12月 21日
URL 任意
DOI 任意 10.1038/s41598-017-18339-1    (→Scopusで検索)
PMID 任意 29269791    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1038/s41598-017-18339-1

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article