342298: Koyama Teruhide/Kuriyama Nagato/Ozaki Etsuko/Matsui Daisuke/Watanabe Isao/Takeshita Wakiko/Iwai Komei/Watanabe Yoshiyuki/Nakatochi Masahiro/Shimanoe Chisato/Tanaka Keitaro/Oze Isao/Ito Hidemi/[上村浩一]/[勝浦-釜野桜子]/Ibusuki Rie/Shimoshikiryo Ippei/Takashima Naoyuki/Kadota Aya/Kawai Sayo/Sasakabe Tae/Okada Rieko/Hishida Asahi/Naito Mariko/Kuriki Kiyonori/Endoh Kaori/Furusyo Norihiro/Ikezaki Hiroaki/Suzuki Sadao/Hosono Akihiro/Mikami Haruo/Nakamura Yohko/Kubo Michiaki/Wakai Kenji/Genetic Variants of RAMP2 and CLR are Associated with Stroke./[Journal of Atherosclerosis and Thrombosis]

著作: Koyama Teruhide/Kuriyama Nagato/Ozaki Etsuko/Matsui Daisuke/Watanabe Isao/Takeshita Wakiko/Iwai Komei/Watanabe Yoshiyuki/Nakatochi Masahiro/Shimanoe Chisato/Tanaka Keitaro/Oze Isao/Ito Hidemi/[上村浩一]/[勝浦-釜野桜子]/Ibusuki Rie/Shimoshikiryo Ippei/Takashima Naoyuki/Kadota Aya/Kawai Sayo/Sasakabe Tae/Okada Rieko/Hishida Asahi/Naito Mariko/Kuriki Kiyonori/Endoh Kaori/Furusyo Norihiro/Ikezaki Hiroaki/Suzuki Sadao/Hosono Akihiro/Mikami Haruo/Nakamura Yohko/Kubo Michiaki/Wakai Kenji/Genetic Variants of RAMP2 and CLR are Associated with Stroke./[Journal of Atherosclerosis and Thrombosis]

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EID: 342298
EOID: 918017
Map: 0
LastModified: 2018年8月8日(水) 18:24:36
Operator: 上村浩一
Avail: TRUE
Censor: 承認済
Owner: 上村浩一
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種別

必須

学術論文(審査論文)

言語

必須

英語

招待

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審査

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カテゴリ

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共著種別

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学究種別

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組織

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著者

必須

(英) Koyama Teruhide

役割任意

貢献度任意

学籍番号推奨
(英) Kuriyama Nagato

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貢献度任意

学籍番号推奨
(英) Ozaki Etsuko

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貢献度任意

学籍番号推奨
(英) Matsui Daisuke

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貢献度任意

学籍番号推奨
(英) Watanabe Isao

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貢献度任意

学籍番号推奨
(英) Takeshita Wakiko

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学籍番号推奨
(英) Iwai Komei

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学籍番号推奨
(英) Watanabe Yoshiyuki

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学籍番号推奨
(英) Nakatochi Masahiro

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学籍番号推奨
(英) Shimanoe Chisato

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学籍番号推奨
(英) Tanaka Keitaro

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学籍番号推奨
(英) Oze Isao

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学籍番号推奨
(英) Ito Hidemi

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学籍番号推奨
上村浩一

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学籍番号推奨
勝浦-釜野桜子([徳島大学.大学院ヘルスバイオサイエンス研究部.医療創生科学部門.社会環境衛生学講座.予防医学]/->個人[釜野桜子])

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(英) Ibusuki Rie

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(英) Shimoshikiryo Ippei

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(英) Takashima Naoyuki

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(英) Kadota Aya

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(英) Kawai Sayo

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(英) Sasakabe Tae

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(英) Okada Rieko

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(英) Hishida Asahi

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(英) Naito Mariko

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(英) Kuriki Kiyonori

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(英) Endoh Kaori

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(英) Furusyo Norihiro

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(英) Ikezaki Hiroaki

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学籍番号推奨
(英) Suzuki Sadao

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(英) Hosono Akihiro

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(英) Mikami Haruo

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(英) Nakamura Yohko

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(英) Kubo Michiaki

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(英) Wakai Kenji

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題名

必須

(英) Genetic Variants of RAMP2 and CLR are Associated with Stroke.

副題

任意

要約

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(英) Stroke is associated closely with vascular homeostasis, and several complex processes and interacting pathways, which involve various genetic and environmental factors, contribute to the risk of stroke. Although adrenomedullin (ADM) has a number of physiological and vasoprotective functions, there are few studies of the ADM receptor system in humans. The ADM receptor comprises a calcitonin-receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMPs). We analyzed single nucleotide polymorphisms (SNPs) in the RAMP2 and CLR genes to determine their association with stroke in the light of gene-environment interactions. Using cross-sectional data from the Japan Multi-Institutional Collaborative Cohort Study in the baseline surveys, 14,087 participants from 12 research areas were genotyped. We conducted a hypothesis-based association between stroke prevalence and SNPs in the RAMP2 and CLR genes based on data abstracted from two SNPs in RAMP2 and 369 SNPs in CLR. We selected five SNPs from among the CLR variants (rs77035639, rs3815524, rs75380157, rs574603859, and rs147565266) and one RAMP2 SNP (rs753152), which were associated with stroke, for analysis. Five of the SNPs (rs77035639, rs3815524, rs75380157, rs147565266, and rs753152) showed no significant association with obesity, ischemic heart disease, hypertension, dyslipidemia, and diabetes. In the logistic regression analysis, rs574603859 had a lower odds ratio (0.238; 95% confidence interval, 0.076-0.745, adjusted for age, sex, and research area) and the other SNPs had higher odds ratios for association with stroke. This was the first study to investigate the relationships between ADM receptor genes (RAMP2 and CLR) and stroke in the light of gene-environment interactions in human.

キーワード

推奨

(英) Biomarkers
(英) Calcitonin Receptor-Like Protein
(英) Cohort Studies
(英) Cross-Sectional Studies
(英) Female
(英) Follow-Up Studies
(英) Humans
(英) Male
(英) Middle Aged
(英) Polymorphism, Single Nucleotide
(英) Prognosis
(英) Receptor Activity-Modifying Protein 2
(英) Stroke

発行所

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誌名

必須

Journal of Atherosclerosis and Thrombosis(日本動脈硬化学会)

(pISSN: 1340-3478, eISSN: 1880-3873)

ISSN	任意	1880-3873 ISSN: 1340-3478 (pISSN: 1340-3478, eISSN: 1880-3873) Title: Journal of atherosclerosis and thrombosis Title(ISO): J Atheroscler Thromb Supplier: 一般社団法人日本動脈硬化学会 Publisher: Japan Atherosclerosis Society (NLM Catalog) (医中誌Web) (J-STAGE) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

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号

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頁

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1267 1281

都市

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年月日

必須

2017年 9月 14日

URL

任意

DOI

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10.5551/jat.41517 (→Scopusで検索)

PMID

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28904253 (→Scopusで検索)

CRID

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Scopus

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備考

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(英) Article.ELocationID: 10.5551/jat.41517
(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) KeywordList.Keyword: Adrenomedullin
(英) KeywordList.Keyword: Calcitonin-receptor-like receptor
(英) KeywordList.Keyword: Receptor activity-modifying protein 2
(英) KeywordList.Keyword: Stroke

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