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著作: Yamasaki K/Nakagawa H/[久保 宜明]/Ootaki K/Efficacy and safety of brodalumab in patients with generalized pustular psoriasis and psoriatic erythroderma: results from a 52-week, open-label study./[The British Journal of Dermatology]

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EID
342245
EOID
923349
Map
0
LastModified
2018年8月27日(月) 20:21:42
Operator
大家 隆弘
Avail
TRUE
Censor
0
Owner
久保 宜明
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Yamasaki K
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Nakagawa H
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 久保 宜明([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.皮膚科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Ootaki K
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Efficacy and safety of brodalumab in patients with generalized pustular psoriasis and psoriatic erythroderma: results from a 52-week, open-label study.

副題 任意
要約 任意

(英) A T-helper (Th) cell subset Th17 preferentially produces interleukin (IL)-17 and plays a pivotal role in the pathogenesis of psoriasis. However, the pathological roles of IL-17 cascades in generalized pustular psoriasis (GPP) and psoriatic erythroderma (PsE) have not been well established. To evaluate the efficacy and safety of brodalumab, a human immunoglobulin G2 monoclonal antibody against human IL-17-receptor A (IL-17RA), in Japanese patients with GPP and PsE. This was an open-label, multicentre, long-term phase III study in Japanese patients with rare and severe types of psoriasis. Patients received brodalumab 140 mg at day 1 and weeks 1 and 2, and then every 2 weeks until week 52. The primary endpoint was the Clinical Global Impression of Improvement (CGI). Safety evaluations included treatment-emergent adverse events (AEs) and changes in laboratory parameters. A total of 12 patients with GPP and 18 with PsE were enrolled. Ten patients with GPP and 16 with PsE completed the study. At week 52 (last observation carried forward), CGI remission or improvement was achieved in 11 patients with GPP and 18 with PsE. The most commonly reported AE was nasopharyngitis (33 3%). Five serious AEs occurred during the study. However, none was considered treatment-related. Brodalumab significantly improved the symptoms of patients with GPP and PsE throughout the 52 weeks, and demonstrated favourable safety profiles without any new safety signals. Inhibition of IL-17RA-mediated signalling by brodalumab is expected to be a promising new treatment option for patients with GPP and PsE.

キーワード 推奨
  1. (英) Adult
  2. (英) Antibodies, Monoclonal
  3. (英) Dermatitis, Exfoliative
  4. (英) Dermatologic Agents
  5. (英) Dose-Response Relationship, Drug
  6. (英) Drug Administration Schedule
  7. (英) Female
  8. (英) Humans
  9. (英) Injections, Subcutaneous
  10. (英) Long-Term Care
  11. (英) Male
  12. (英) Middle Aged
  13. (英) Psoriasis
  14. (英) Treatment Outcome
発行所 推奨
誌名 必須 The British Journal of Dermatology(British Association of Dermatologists)
(pISSN: 0007-0963, eISSN: 1365-2133)
ISSN 任意 1365-2133
ISSN: 0007-0963 (pISSN: 0007-0963, eISSN: 1365-2133)
Title: The British journal of dermatology
Title(ISO): Br J Dermatol
Supplier: British Association of Dermatologists
Publisher: Blackwell
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 176
必須 3
必須 741 751
都市 任意
年月日 必須 2017年 3月 初日
URL 任意
DOI 任意 10.1111/bjd.14702    (→Scopusで検索)
PMID 任意 27106510    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1111/bjd.14702

  2. (英) Article.PublicationTypeList.PublicationType: Clinical Trial, Phase III

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) Article.PublicationTypeList.PublicationType: Multicenter Study