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著作: 前川 秀継/[多田 恵曜]/[八木 謙次]/[宮本 健志]/Keiko T. Kitazato/[高麗 雅章]/[里見 淳一郎]/Hashimoto Tomoki/[永廣 信治]/Bazedoxifene, a selective estrogen receptor modulator, reduces cerebral aneurysm rupture in Ovariectomized rats./[Journal of Neuroinflammation]

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EID
341963
EOID
937717
Map
0
LastModified
2019年1月15日(火) 15:25:43
Operator
三木 ちひろ
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TRUE
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Owner
永廣 信治
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Maekawa Hidetsugu / (日) 前川 秀継 / (読) まえかわ ひでつぐ
    役割 任意
    貢献度 任意
    学籍番号 推奨 ****
  2. 多田 恵曜([徳島大学.病院.中央診療施設等.てんかんセンター])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 八木 謙次
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 宮本 健志([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学]/[徳島大学.病院.診療科.脳·神経·精神科.脳神経外科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Keiko T. Kitazato
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 高麗 雅章
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. 里見 淳一郎
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Hashimoto Tomoki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. 永廣 信治
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Bazedoxifene, a selective estrogen receptor modulator, reduces cerebral aneurysm rupture in Ovariectomized rats.

副題 任意
要約 任意

(英) Estrogen deficiency is thought to be responsible for the higher frequency of aneurysmal subarachnoid hemorrhage in post- than premenopausal women. Estrogen replacement therapy appears to reduce this risk but is associated with significant side effects. We tested our hypothesis that bazedoxifene, a clinically used selective estrogen receptor (ER) modulator with fewer estrogenic side effects, reduces cerebral aneurysm rupture in a new model of ovariectomized rats. Ten-week-old female Sprague-Dawley rats were subjected to ovariectomy, hemodynamic changes, and hypertension to induce aneurysms (ovariectomized aneurysm rats) and treated with vehicle or with 0.3 or 1.0 mg/kg/day bazedoxifene. They were compared with sham-ovariectomized rats subjected to hypertension and hemodynamic changes (HT rats). The vasoprotective effects of bazedoxifene and the mechanisms underlying its efficacy were analyzed. During 12 weeks of observation, the incidence of aneurysm rupture was 52% in ovariectomized rats. With no effect on the blood pressure, treatment with 0.3 or 1.0 mg/kg/day bazedoxifene lowered this rate to 11 and 17%, almost the same as in HT rats (17%). In ovariectomized rats, the mRNA level of ERα, ERβ, and the tissue inhibitor of metalloproteinase-2 was downregulated in the cerebral artery prone to rupture at 5 weeks after aneurysm induction; the mRNA level of interleukin-1β and the matrix metalloproteinase-9 was upregulated. In HT rats, bazedoxifene restored the mRNA level of ERα and ERβ and decreased the level of interleukin-1β and matrix metalloproteinase-9. These findings suggest that bazedoxifene was protective against aneurysmal rupture by alleviating the vascular inflammation and degradation exacerbated by the decrease in ERα and ERβ. Our observation that bazedoxifene decreased the incidence of aneurysmal rupture in ovariectomized rats warrants further studies to validate this response in humans.

キーワード 推奨
  1. (英) Animals
  2. 血圧(blood pressure)
  3. (英) Cerebral Arteries
  4. (英) Cytokines
  5. (英) Disease Models, Animal
  6. (英) Dose-Response Relationship, Drug
  7. (英) Estrogen Receptor alpha
  8. (英) Estrogen Receptor beta
  9. (英) Female
  10. (英) Gene Expression Regulation
  11. 高血圧(hypertension)
  12. (英) Indoles
  13. (英) Intracranial Aneurysm
  14. (英) Matrix Metalloproteinase 2
  15. (英) Ovariectomy
  16. (英) RNA, Messenger
  17. (英) Rats
  18. (英) Rats, Sprague-Dawley
  19. (英) Salts
  20. (英) Selective Estrogen Receptor Modulators
  21. (英) Tissue Inhibitor of Metalloproteinase-2
発行所 推奨
誌名 必須 Journal of Neuroinflammation([BioMed Central Ltd.])
(eISSN: 1742-2094)
ISSN 任意 1742-2094
ISSN: 1742-2094 (eISSN: 1742-2094)
Title: Journal of neuroinflammation
Title(ISO): J Neuroinflammation
Publisher: BioMed Central
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 2
必須 14
必須 197 197
都市 任意
年月日 必須 2017年 10月 2日
URL 任意
DOI 任意 10.1186/s12974-017-0966-7    (→Scopusで検索)
PMID 任意 28969701    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意 2-s2.0-85030714321
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1186/s12974-017-0966-7

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) KeywordList.Keyword: Estrogen

  4. (英) KeywordList.Keyword: Estrogen receptor

  5. (英) KeywordList.Keyword: Intracranial aneurysm

  6. (英) KeywordList.Keyword: Selective estrogen receptor modulator

  7. (英) KeywordList.Keyword: Subarachnoid hemorrhage