341872: Takiguchi Kazuo/Uezato Akihito/Itasaka Michio/Atsuta Hidenori/Narushima Kenji/Yamamoto Naoki/Kurumaji Akeo/Tomita Makoto/Oshima Kazunari/Shoda Kosaku/Tamaru Mai/[中瀧理仁]/Okazaki Mitsutoshi/Ishiwata Sayuri/Ishiwata Yasuyoshi/Yasuhara Masato/Arima Kunimasa/[大森哲郎]/Nishikawa Toru/Association of schizophrenia onset age and white matter integrity with treatment effect of D-cycloserine: a randomized placebo-controlled double-blind crossover study./[BMC Psychiatry]

著作: Takiguchi Kazuo/Uezato Akihito/Itasaka Michio/Atsuta Hidenori/Narushima Kenji/Yamamoto Naoki/Kurumaji Akeo/Tomita Makoto/Oshima Kazunari/Shoda Kosaku/Tamaru Mai/[中瀧理仁]/Okazaki Mitsutoshi/Ishiwata Sayuri/Ishiwata Yasuyoshi/Yasuhara Masato/Arima Kunimasa/[大森哲郎]/Nishikawa Toru/Association of schizophrenia onset age and white matter integrity with treatment effect of D-cycloserine: a randomized placebo-controlled double-blind crossover study./[BMC Psychiatry]

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EID: 341872
EOID: 937595
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LastModified: 2019年1月9日(水) 15:33:28
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種別

必須

学術論文(審査論文)

言語

必須

英語

招待

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審査

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カテゴリ

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共著種別

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学究種別

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組織

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著者

必須

(英) Takiguchi Kazuo

役割任意

貢献度任意

学籍番号推奨
(英) Uezato Akihito

役割任意

貢献度任意

学籍番号推奨
(英) Itasaka Michio

役割任意

貢献度任意

学籍番号推奨
(英) Atsuta Hidenori

役割任意

貢献度任意

学籍番号推奨
(英) Narushima Kenji

役割任意

貢献度任意

学籍番号推奨
(英) Yamamoto Naoki

役割任意

貢献度任意

学籍番号推奨
(英) Kurumaji Akeo

役割任意

貢献度任意

学籍番号推奨
(英) Tomita Makoto

役割任意

貢献度任意

学籍番号推奨
(英) Oshima Kazunari

役割任意

貢献度任意

学籍番号推奨
(英) Shoda Kosaku

役割任意

貢献度任意

学籍番号推奨
(英) Tamaru Mai

役割任意

貢献度任意

学籍番号推奨
中瀧理仁([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.精神医学]/[徳島大学.病院.診療科.脳·神経·精神科.精神科神経科])

役割任意

貢献度任意

学籍番号推奨
(英) Okazaki Mitsutoshi

役割任意

貢献度任意

学籍番号推奨
(英) Ishiwata Sayuri

役割任意

貢献度任意

学籍番号推奨
(英) Ishiwata Yasuyoshi

役割任意

貢献度任意

学籍番号推奨
(英) Yasuhara Masato

役割任意

貢献度任意

学籍番号推奨
(英) Arima Kunimasa

役割任意

貢献度任意

学籍番号推奨
大森哲郎

役割任意

貢献度任意

学籍番号推奨
(英) Nishikawa Toru

役割任意

貢献度任意

学籍番号推奨

題名

必須

(英) Association of schizophrenia onset age and white matter integrity with treatment effect of D-cycloserine: a randomized placebo-controlled double-blind crossover study.

副題

任意

要約

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(英) It has been reported that drugs which promote the N-Methyl-D-aspartate-type glutamate receptor function by stimulating the glycine modulatory site in the receptor improve negative symptoms and cognitive dysfunction in schizophrenia patients being treated with antipsychotic drugs. We performed a placebo-controlled double-blind crossover study involving 41 schizophrenia patients in which D-cycloserine 50 mg/day was added-on, and the influence of the onset age and association with white matter integrity on MR diffusion tensor imaging were investigated for the first time. The patients were evaluated using the Positive and Negative Syndrome Scale (PANSS), Scale for the Assessment of Negative Symptoms (SANS), Brief Assessment of Cognition in Schizophrenia (BACS), and other scales. D-cycloserine did not improve positive or negative symptoms or cognitive dysfunction in schizophrenia. The investigation in consideration of the onset age suggests that D-cycloserine may aggravate negative symptoms of early-onset schizophrenia. The better treatment effect of D-cycloserine on BACS was observed when the white matter integrity of the sagittal stratum/ cingulum/fornix stria terminalis/genu of corpus callosum/external capsule was higher, and the better treatment effect on PANSS general psychopathology (PANSS-G) was observed when the white matter integrity of the splenium of corpus callosum was higher. In contrast, the better treatment effect of D-cycloserine on PANSS-G and SANS-IV were observed when the white matter integrity of the posterior thalamic radiation (left) was lower. It was suggested that response to D-cycloserine is influenced by the onset age and white matter integrity. UMIN Clinical Trials Registry (number UMIN000000468 ). Registered 18 August 2006.

キーワード

推奨

(英) Adult
(英) Age of Onset
(英) Antipsychotic Agents
(英) Cross-Over Studies
(英) Cycloserine
(英) Diffusion Tensor Imaging
(英) Double-Blind Method
(英) Drug Therapy, Combination
(英) Female
(英) Glycine Agents
(英) Humans
(英) Male
(英) Middle Aged
統合失調症(schizophrenia)
(英) Schizophrenic Psychology
(英) White Matter

発行所

推奨

誌名

必須

BMC Psychiatry([BioMed Central Ltd.])

(eISSN: 1471-244X)

ISSN	任意	1471-244X ISSN: 1471-244X (eISSN: 1471-244X) Title: BMC psychiatry Title(ISO): BMC Psychiatry Publisher: BioMed Central (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

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号

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頁

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249 249

都市

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年月日

必須

2017年 7月 12日

URL

任意

DOI

任意

10.1186/s12888-017-1410-3 (→Scopusで検索)

PMID

任意

28701225 (→Scopusで検索)

CRID

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WOS

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Scopus

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2-s2.0-85023199149

評価値

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被引用数

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指導教員

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備考

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(英) Article.ELocationID: 10.1186/s12888-017-1410-3
(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) Article.PublicationTypeList.PublicationType: Randomized Controlled Trial
(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't
(英) KeywordList.Keyword: Crossover
(英) KeywordList.Keyword: D-cycloserine
(英) KeywordList.Keyword: Double-blind
(英) KeywordList.Keyword: Glutamate
(英) KeywordList.Keyword: MR diffusion tensor imaging
(英) KeywordList.Keyword: Placebo-controlled
(英) KeywordList.Keyword: Randomized
(英) KeywordList.Keyword: Schizophrenia

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