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著作: [玉谷 哲也]/[髙丸 菜都美]/[大江 剛]/秋田 和也/[中川 貴之]/[宮本 洋二]/Expression of CD44,CD44v9ABCG2, CD24,Bmi-1 and ALDH1 in stage andoral spuamous cell carcinoma and their association with clinicopathological factors/[Oncology Letters]

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EID
339926
EOID
932298
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0
LastModified
2018年11月26日(月) 16:08:20
Operator
大家 隆弘
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宮本 洋二
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
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著者 必須
  1. 玉谷 哲也
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  2. 髙丸 菜都美([徳島大学.病院.診療科.歯科口腔外科.口腔外科])
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    貢献度 任意
    学籍番号 推奨
  3. 大江 剛
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    学籍番号 推奨
  4. (英) Akita Kazuya / (日) 秋田 和也
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    学籍番号 推奨
  5. 中川 貴之
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  6. 宮本 洋二([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔外科学])
    役割 任意
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題名 必須

(英) Expression of CD44,CD44v9ABCG2, CD24,Bmi-1 and ALDH1 in stage andoral spuamous cell carcinoma and their association with clinicopathological factors

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(英) Cancer stem cells (CSCs) exhibit self-replication, self-differentiation, drug resistance and immune evasion activities. In recent years CSCs have become increasingly important for the treatment of malignant tumors. CSCs express specific markers, including cluster of differentiation (CD)44, CD44 variant 9 (CD44v9), ATP-binding cassette sub-family G member 2 (ABCG2), CD24, B lymphoma Mo-MLV insertion region 1 homolog (BMI-1) and aldehyde dehydrogenase 1 (ALDH1). However, the prognostic value of their expression in patients with oral squamous cell carcinoma (OSCC) are not well known. The present study evaluated these markers in stage I and II patients with OSCC and examined the association between T classification, histological differentiation, classification of invasion mode, lymph node metastasis and disease-free survival rate. Tissue specimens were obtained from 70 patients with stage I or II OSCC following either surgery or biopsy. Immunohistochemistry was performed and positive staining was defiend as 10% positive cells. CD44 and CD44v9 expressions were strongly detected in all OSCC tissues compared with normal epithelial cells. A total of 22 (31.4%) cases expressed ABCG2 and there was a significant association between ABCG2 expression and invasion. A total of 41 cases (59.0%) expressed CD24 and there was a significant association between CD24 expression and invasion. A total of 33 cases (47.1%) expressed BMI-1 and there was a significant association between BMI-1 expression and the disease-free survival rate. A total of 18 cases (25.7%) expressed ALDH1. Although there was no association between ALDH1 expression and T classification, there were significant associations between ALDH1 expression and histological differentiation, invasion mode, metastasis and the disease-free survival rate. Multivariate analysis revealed that ALDH1 expression was the only prognostic factor for disease-free survival rate. The results of the present study suggest that the positivity of ALDH1 detected in patients with OSCC correlates with the number of cells undergoing epithelial mesenchymal transition and metastasis. These findings indicated that the expression of ALDH1 may be an effective prognostic marker indicating the survival of patients with stage I and II OSCC.

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誌名 必須 Oncology Letters(Spandidos Publications)
(pISSN: 1792-1074, eISSN: 1792-1082)
ISSN 任意 1792-1074
ISSN: 1792-1074 (pISSN: 1792-1074, eISSN: 1792-1082)
Title: Oncology letters
Title(ISO): Oncol Lett
Publisher: Spandidos Publications
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 16
必須 1
必須 1133 1140
都市 任意
年月日 必須 2018年 6月 初日
URL 任意
DOI 任意 10.3892/ol.2018.8703    (→Scopusで検索)
PMID 任意 29963189    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意 2-s2.0-85047608360
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  1. (英) Article.ELocationID: 10.3892/ol.2018.8703

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) KeywordList.Keyword: ATP-binding cassette sub-family G member 2

  4. (英) KeywordList.Keyword: B lymphoma Mo-MLV insertion region 1 homolog

  5. (英) KeywordList.Keyword: aldehyde dehydrogenase 1

  6. (英) KeywordList.Keyword: cluster of differentiation 24

  7. (英) KeywordList.Keyword: cluster of differentiation 44

  8. (英) KeywordList.Keyword: cluster of differentiation 44 variant 9

  9. (英) KeywordList.Keyword: oral cancer