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著作: [有澤 孝吉]/Recent decreasing trends of exposure to PCDDs/PCDFs/dioxin-like PCBs in general populations, and associations with diabetes, metabolic syndrome, and gout/hyperuricemia/[The Journal of Medical Investigation : JMI]

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EID
339858
EOID
932971
Map
0
LastModified
2018年11月29日(木) 11:56:18
Operator
[ADMIN]
Avail
TRUE
Censor
0
Owner
有澤 孝吉
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨 研究
共著種別 推奨 単独著作(徳島大学内の単一の研究グループ(研究室等)内の研究 (単著も含む))
学究種別 推奨
組織 推奨
著者 必須
  1. 有澤 孝吉([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.社会医学系.予防医学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Recent decreasing trends of exposure to PCDDs/PCDFs/dioxin-like PCBs in general populations, and associations with diabetes, metabolic syndrome, and gout/hyperuricemia

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(英) The author reviewed recent reports about the blood levels and dietary intake of polychlorinated dibenzo-p-dioxins (PCDDs)/furans (PCDFs)/dioxin-like polychlorinated biphenyls (DL-PCBs) to investigate the trends of dioxin exposure, and epidemiologic studies on the associations of blood levels of dioxins with metabolic diseases. In recent years, dietary intake of dioxins has been decreasing, and the means are equal to or less than 1.0 pg Toxic Equivalents (TEQ)/kg/day in the general populations of several countries. The blood levels of dioxins are also decreasing, probably because of reduced dietary intake. Many cross-sectional studies reported positive associations between blood levels of some isomers or TEQ-based concentrations of PCDDs/PCDFs/DL-PCBs and diabetes in general populations. Three cohort studies on populations with heavy exposure and two nested case-control studies on general populations have also been published, but the results are inconsistent. Three large-scale cross-sectional studies and two cohort studies reported an association between blood levels of some isomers or TEQ-based concentrations of PCDDs/PCDFs/DL-PCBs and metabolic syndrome. In addition, three cross-sectional studies reported significant positive associations with gout/hyperuricemia. Further prospective studies and experimental studies are needed to establish cause-effect relationships, and to clarify the biological mechanisms for the association between background exposure to dioxins and potential health effects. J. Med. Invest. 65:151-161, August, 2018.

キーワード 推奨
発行所 推奨
誌名 必須 The Journal of Medical Investigation : JMI([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
ISSN 任意 1349-6867
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 65
必須 3.4
必須 151 161
都市 任意
年月日 必須 2018年 6月 14日
URL 任意
DOI 任意 10.2152/jmi.65.151    (→Scopusで検索)
PMID 任意 30282853    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意
機関リポジトリ 112230
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.2152/jmi.65.151

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) KeywordList.Keyword: Diabetes

  4. (英) KeywordList.Keyword: Dioxins

  5. (英) KeywordList.Keyword: Gout

  6. (英) KeywordList.Keyword: Insulin resistance

  7. (英) KeywordList.Keyword: Metabolic syndrome