著作: Kishida Takumi/Akiyoshi Kenji/Erdenebat Erdenedalai/Anu Enhetomuru/[今井 昭二]/[小山 保夫]/Cellular adverse actions of dibromoacetonitrile, a by-product in water bacterial control, at sublethal levels in rat thymocytes/[Toxicology In Vitro]/[小山 保夫]
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種別 | 必須 | 学術論文(審査論文) | |||
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言語 | 必須 | 英語 | |||
招待 | 推奨 | ||||
審査 | 推奨 | Peer Review | |||
カテゴリ | 推奨 | 教育 | |||
共著種別 | 推奨 | 学内共著(徳島大学内研究者との共同研究 (学外研究者を含まない)) | |||
学究種別 | 推奨 | 学士課程学生による研究報告 | |||
組織 | 推奨 |
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著者 | 必須 | ||||
題名 | 必須 |
(英) Cellular adverse actions of dibromoacetonitrile, a by-product in water bacterial control, at sublethal levels in rat thymocytes |
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副題 | 任意 | ||||
要約 | 任意 |
(英) The aim of this study was to investigate the effects of dibromoacetonitrile (DBAN), a by-product in water bacterial control, at sublethal concentrations on rat thymocytes, by using a cytometric technique with appropriate fluorescent dyes. By using this method, the possibility that DBAN induces cellular actions related to oxidative stress was assessed. DBAN reduced the content of cellular nonprotein thiols under Zn2+-free conditions. It elevated the intracellular level of Zn2+, being independent from external Zn2+. DBAN increased cell vulnerability to the cytotoxic action of hydrogen peroxide. These actions of DBAN were likely related to oxidative stress. DBAN is formed by the reaction of bromides and chlorinated oxidants during water disinfection. Hydrolysis of 2,2-dibromo-3-nitrilopropionamide, an antimicrobial used in hydraulic fracturing fluids for production of shale gas and oil, produces DBAN. Therefore, the concern regarding the levels of DBAN in industrial water systems is necessary to avoid the environmental risk to humans and wild mammals. |
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キーワード | 推奨 |
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発行所 | 推奨 | ||||
誌名 | 必須 |
Toxicology In Vitro(British Industrial Biological Research Association)
(pISSN: 0887-2333, eISSN: 1879-3177)
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巻 | 必須 | 51 | |||
号 | 必須 | --- | |||
頁 | 必須 | 145 149 | |||
都市 | 任意 | アムステルダム(Amsterdam/[オランダ王国]) | |||
年月日 | 必須 | 2018年 6月 初日 | |||
URL | 任意 | ||||
DOI | 任意 | 10.1016/j.tiv.2018.05.011 (→Scopusで検索) | |||
PMID | 任意 | ||||
CRID | 任意 | ||||
WOS | 任意 | ||||
Scopus | 任意 | 2-s2.0-85047492648 | |||
機関リポジトリ | 111989 | ||||
評価値 | 任意 | ||||
被引用数 | 任意 | ||||
指導教員 | 推奨 | ||||
備考 | 任意 |