著作: [岩佐 武]/[松崎 利也]/馬依拉 伊利亜斯/[矢野 清人]/[苛原 稔]/The effects of chronic testosterone administration on body weight, food intake, and fat weight were age-dependent./[Steroids]
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削除する| 種別 | 必須 | 学術論文(審査論文) | |||
|---|---|---|---|---|---|
| 言語 | 必須 | 英語 | |||
| 招待 | 推奨 | ||||
| 審査 | 推奨 | ||||
| カテゴリ | 推奨 | ||||
| 共著種別 | 推奨 | ||||
| 学究種別 | 推奨 | ||||
| 組織 | 推奨 | ||||
| 著者 | 必須 | ||||
| 題名 | 必須 |
(英) The effects of chronic testosterone administration on body weight, food intake, and fat weight were age-dependent. |
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| 副題 | 任意 | ||||
| 要約 | 任意 |
(英) Previously, we showed that chronic testosterone administration increased body weight (BW) and food intake (FI), but did not alter fat weight, in young female rats. To examine our hypothesis that the effects of androgens on BW, FI and body composition might be age-dependent, the effects of chronic testosterone administration were evaluated in rats of different ages; i.e., young and middle-aged rats. Although chronic testosterone administration increased BW gain, FI, and feed efficiency in both young and middle-aged rats, it increased visceral fat weight in middle-aged rats, but not in young rats. Therefore, it is possible that testosterone promotes the conversion of energy to adipose tissue and exacerbates fat accumulation in older individuals. In addition, although the administration of testosterone increased the serum leptin level, it did not alter hypothalamic neuropeptide Y mRNA expression in middle-aged rats. On the contrary, the administration of testosterone did not affect the serum leptin levels of young rats. Thus, testosterone might induce hypothalamic leptin resistance, which could lead to fat accumulation in older individuals. Testosterone might disrupt the mechanisms that protect against adiposity and hyperphagia and represent a risk factor for excessive body weight and obesity, especially in older females. |
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| キーワード | 推奨 | ||||
| 発行所 | 推奨 | ||||
| 誌名 | 必須 |
Steroids([Elsevier])
(pISSN: 0039-128X, eISSN: 1878-5867)
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| 巻 | 必須 | 127 | |||
| 号 | 必須 | --- | |||
| 頁 | 必須 | 18 23 | |||
| 都市 | 任意 | ||||
| 年月日 | 必須 | 2017年 9月 8日 | |||
| URL | 任意 | ||||
| DOI | 任意 | 10.1016/j.steroids.2017.08.014 (→Scopusで検索) | |||
| PMID | 任意 | 28893558 (→Scopusで検索) | |||
| CRID | 任意 | ||||
| WOS | 任意 | ||||
| Scopus | 任意 | ||||
| 機関リポジトリ | 112453 | ||||
| 評価値 | 任意 | ||||
| 被引用数 | 任意 | ||||
| 指導教員 | 推奨 | ||||
| 備考 | 任意 |
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