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著作: [後東 久嗣]/[西岡 安彦]/Fibrocytes: A Novel Stromal Cells to Regulate Resistance to Anti-Angiogenic Therapy and Cancer Progression/[International Journal of Molecular Sciences]

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EID
338635
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2018年11月29日(木) 11:57:25
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西岡 安彦
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種別 必須 総説·解説
言語 必須 英語
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著者 必須
  1. 後東 久嗣
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  2. 西岡 安彦([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学])
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題名 必須

(英) Fibrocytes: A Novel Stromal Cells to Regulate Resistance to Anti-Angiogenic Therapy and Cancer Progression

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(英) An adequate blood supply is essential for cancer cells to survive and grow; thus, the concept of inhibiting tumor angiogenesis has been applied to cancer therapy, and several drugs are already in clinical use. It has been shown that treatment with those anti-angiogenic drugs improved the response rate and prolonged the survival of patients with various types of cancer; however, it is also true that the effect was mostly limited. Currently, the disappointing clinical results are explained by the existence of intrinsic or acquired resistance to the therapy mediated by both tumor cells and stromal cells. This article reviews the mechanisms of resistance mediated by stromal cells such as endothelial cells, pericytes, fibroblasts and myeloid cells, with an emphasis on fibrocytes, which were recently identified as the cell type responsible for regulating acquired resistance to anti-angiogenic therapy. In addition, the other emerging role of fibrocytes as mediator-producing cells in tumor progression is discussed.

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誌名 必須 International Journal of Molecular Sciences(Molecular Diversity Preservation International/Multidisciplinary Digital Publishing Institute)
(pISSN: 1661-6596, eISSN: 1422-0067)
ISSN 任意 1422-0067
ISSN: 1661-6596 (pISSN: 1661-6596, eISSN: 1422-0067)
Title: International journal of molecular sciences
Title(ISO): Int J Mol Sci
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 19
必須 1
必須 98 98
都市 任意
年月日 必須 2018年 1月 初日
URL 任意
DOI 任意 10.3390/ijms19010098    (→Scopusで検索)
PMID 任意 29286323    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意 2-s2.0-85039915228
機関リポジトリ 112410
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被引用数 任意
指導教員 推奨
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  1. (英) Article.ELocationID: E98

  2. (英) Article.ELocationID: 10.3390/ijms19010098

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) Article.PublicationTypeList.PublicationType: Review

  5. (英) KeywordList.Keyword: angiogenesis

  6. (英) KeywordList.Keyword: anti-angiogenic therapy

  7. (英) KeywordList.Keyword: cancer

  8. (英) KeywordList.Keyword: fibrocyte

  9. (英) KeywordList.Keyword: resistance

  10. (英) KeywordList.Keyword: tumor stroma

  11. (英) CoiStatement: The authors declare no conflict of interest.