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著作: [早渕 康信]/Akemi Ono/Yukako Homma/[香美 祥二]/Analysis of Right Ventricular Myocardial Stiffness and Relaxation Components in Children and Adolescents With Pulmonary Arterial Hypertension./[Journal of the American Heart Association]

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338396
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2019年3月2日(土) 20:41:50
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早渕 康信
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨 研究
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 早渕 康信([徳島大学.病院.中央診療施設等.地域小児科診療部])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Akemi Ono
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Yukako Homma
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 香美 祥二([徳島大学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Analysis of Right Ventricular Myocardial Stiffness and Relaxation Components in Children and Adolescents With Pulmonary Arterial Hypertension.
副題 任意
要約 任意

(英) The rate of left ventricular pressure decrease during isovolumic relaxation is traditionally assessed algebraically via 2 empirical indices: the monoexponential and logistic time constants (τ and τ). Since the pattern of right ventricular (RV) pressure decrease is quite different from that of the left ventricular, we hypothesized that novel kinematic model parameters are more appropriate and useful to evaluate RV diastolic dysfunction. Eight patients with pulmonary arterial hypertension (age 12.5±4.8 years) and 20 normal subjects (control group; age 12.3±4.4 years) were enrolled. The kinematic model was parametrized by stiffness/restoring Ek and damping/relaxation μ. The model predicts isovolumic relaxation pressure as a function of time as the solution of dP/dt+(1/μ)dP/dt+EkP=0, based on the theory that the pressure decay is determined by the interplay of inertial, stiffness/restoring, and damping/relaxation forces. In the assessment of RV diastolic function, τ and τ did not show significant differences between the pulmonary arterial hypertension and control groups (46.8±15.5 ms versus 32.5±14.6 ms, and 19.6±5.9 ms versus 14.5±7.2 ms, respectively). The pulmonary arterial hypertension group had a significantly higher Ek than the control group (915.9±84.2 s versus 487.0±99.6 s, <0.0001) and a significantly lower μ than the control group (16.5±4.3 ms versus 41.1±10.4 ms, <0.0001). These results show that the RV has higher stiffness/elastic recoil and lower cross-bridge relaxation in pulmonary arterial hypertension. The present findings indicate the feasibility and utility of kinematic model parameters for assessing RV diastolic function.
キーワード 推奨
発行所 推奨 Wiley-Blackwell
誌名 必須 Journal of the American Heart Association([American Heart Association]/American Stroke Association)
(eISSN: 2047-9980)
ISSN 任意 2047-9980
ISSN: 2047-9980 (eISSN: 2047-9980)
Title: Journal of the American Heart Association
Title(ISO): J Am Heart Assoc
Publisher: American Heart Association
 (NLM Catalog)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
巻 必須 7
号 必須 9
頁 必須 e008670 e008670
都市 任意
年月日 必須 2018年 4月 19日
URL 任意
DOI 任意 10.1161/JAHA.118.008670    (→Scopusで検索)
PMID 任意 29674337    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意
機関リポジトリ 113033
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意

  1. (英) Article.ELocationID: e008670

  2. (英) Article.ELocationID: 10.1161/JAHA.118.008670

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) KeywordList.Keyword: diastolic function

  5. (英) KeywordList.Keyword: diastolic heart failure

  6. (英) KeywordList.Keyword: pulmonary hypertension

  7. (英) KeywordList.Keyword: relaxation

  8. (英) KeywordList.Keyword: right ventricle

  9. (英) KeywordList.Keyword: right ventricular function

  10. (英) KeywordList.Keyword: right ventricular pressure overload

  11. (英) KeywordList.Keyword: stiffness