徳島大学 教育・研究者情報データベース(EDB)

1. (英) Yoshimoto Ayumi / (日) 吉本 亜由美 / (読) よしもと あゆみ

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2. 上番増 喬([徳島大学.大学院医歯薬学研究部.医学域.先端基礎栄養学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.予防環境栄養学])

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3. 中橋 睦美([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.食料科学系]/->個人[粟飯原 睦美])

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4. 下畑 隆明

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5. 馬渡 一諭

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6. 髙橋 章([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.予防環境栄養学])

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(英) Effect of prenatal administration of low dose antibiotics on gut microbiota and body fat composition of newborn mice.

(英) Several environmental factors during the prenatal period transgenerationally affect the health of newborns in later life. Because low-dose antibiotics have been used for promoting the growth of crops and livestock in agriculture, humans may have ingested residual antibiotics for several decades. However, the effect of prenatal administration of low-dose antibiotics on newborns' health in later life is unclear. In the present study, we found that prenatal treatment of murine mothers with low-dose antibiotics increased the abundance of bacteria of the phylum Firmicutes and the genera Clostridium IV and XIVa in feces from pups. In addition, the body fat percentage of mice in the antibiotic-treated group was higher than those in the control group at 12 weeks of age even though all pups were fed a standard diet. The body fat percentage of all mice was correlated with the abundance of fecal bacteria of Clostridium IV and XIVa. These results predict that low-dose antibiotic administration during the prenatal period affects the gut microbiota of newborns and possibly their health in later life.

1. (英) PublicationType: Journal Article