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著作: [原 英之]/Hironori Miyata/Nandita Rani Das/[千田 淳司]/吉持 盾信/[内山 圭司]/Hitomi Watanabe/Gen Kondoh/Takashi Yokoyama/[坂口 末廣]/Prion Protein Devoid of the Octapeptide Repeat Region Delays BSE Pathogenesis in Mice./[Journal of Virology]

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EID
337787
EOID
1042522
Map
0
LastModified
2022年5月5日(木) 21:19:04
Operator
[ADMIN]
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TRUE
Censor
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Owner
坂口 末廣
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 原 英之([徳島大学.先端酵素学研究所.基幹研究部門])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Hironori Miyata
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Nandita Rani Das / (日) Nandita Rani Das / (読) なんでぃた らに だす
    役割 任意
    貢献度 任意
    学籍番号 推奨 ****
  4. 千田 淳司([徳島大学.先端酵素学研究所.基幹研究部門])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Tatenobu Yoshimochi / (日) 吉持 盾信 / (読) よしもち たてのぶ
    役割 任意
    貢献度 任意
    学籍番号 推奨 ****
  6. 内山 圭司([徳島大学.先端酵素学研究所.重点研究部門])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Hitomi Watanabe
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Gen Kondoh
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. (英) Takashi Yokoyama
    役割 任意
    貢献度 任意
    学籍番号 推奨
  10. 坂口 末廣([徳島大学.先端酵素学研究所.基幹研究部門])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Prion Protein Devoid of the Octapeptide Repeat Region Delays BSE Pathogenesis in Mice.

副題 任意
要約 任意

(英) Conformational conversion of the cellular isoform of prion protein, PrP, into the abnormally folded, amyloidogenic isoform, PrP, is a key pathogenic event in prion diseases, including Creutzfeldt-Jakob disease in humans and scrapie and bovine spongiform encephalopathy (BSE) in animals. We previously reported that the octapeptide repeat (OR) region could be dispensable for converting PrP into PrP after infection with RML prions. We demonstrated that mice transgenically expressing mouse PrP with deletion of the OR region on the PrP knockout background, designated Tg(PrPΔOR)/ mice, did not show reduced susceptibility to RML scrapie prions, with abundant accumulation of PrPΔOR in their brains. We show here that Tg(PrPΔOR)/ mice were highly resistant to BSE prions, developing the disease with markedly elongated incubation times after infection with BSE prions. The conversion of PrPΔOR into PrPΔOR was markedly delayed in their brains. These results suggest that the OR region may have a crucial role in the conversion of PrP into PrP after infection with BSE prions. However, Tg(PrPΔOR)/ mice remained susceptible to RML and 22L scrapie prions, developing the disease without elongated incubation times after infection with RML and 22L prions. PrPΔOR accumulated only slightly less in the brains of RML- or 22L-infected Tg(PrPΔOR)/ mice than PrP in control wild-type mice. Taken together, these results indicate that the OR region of PrP could play a differential role in the pathogenesis of BSE prions and RML or 22L scrapie prions. Structure-function relationship studies of PrP conformational conversion into PrP are worthwhile to understand the mechanism of the conversion of PrP into PrP We show here that, by inoculating Tg(PrPΔOR)/ mice with the three different strains of RML, 22L, and BSE prions, the OR region could play a differential role in the conversion of PrP into PrP after infection with RML or 22L scrapie prions and BSE prions. PrPΔOR was efficiently converted into PrPΔOR after infection with RML and 22L prions. However, the conversion of PrPΔOR into PrPΔOR was markedly delayed after infection with BSE prions. Further investigation into the role of the OR region in the conversion of PrP into PrP after infection with BSE prions might be helpful for understanding the pathogenesis of BSE prions.

キーワード 推奨
  1. (英) Animals
  2. (英) Brain
  3. (英) Cattle
  4. (英) Disease Susceptibility
  5. (英) Encephalopathy, Bovine Spongiform
  6. (英) Humans
  7. (英) Mice
  8. (英) Mice, Transgenic
  9. (英) Oligopeptides
  10. (英) PrPC Proteins
  11. (英) Prion Diseases
  12. (英) Prions
  13. (英) Sequence Deletion
発行所 推奨
誌名 必須 Journal of Virology([アメリカ微生物学会])
(pISSN: 0022-538X, eISSN: 1098-5514)
ISSN 任意 1098-5514
ISSN: 0022-538X (pISSN: 0022-538X, eISSN: 1098-5514)
Title: Journal of virology
Title(ISO): J Virol
Publisher: American Society for Microbiology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 92
必須 1
必須 pii:e01368-17 pii:e01368-17
都市 任意
年月日 必須 2018年 0月 初日
URL 任意
DOI 任意 10.1128/JVI.01368-17    (→Scopusで検索)
PMID 任意 29046443    (→Scopusで検索)
CRID 任意 1050845762396495104
NAID 120006458155
WOS 任意
Scopus 任意
機関リポジトリ 111465
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: e01368-17

  2. (英) Article.ELocationID: 10.1128/JVI.01368-17

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  5. (英) KeywordList.Keyword: BSE

  6. (英) KeywordList.Keyword: bovine spongiform encephalopathy

  7. (英) KeywordList.Keyword: octapeptide repeat

  8. (英) KeywordList.Keyword: prion

  9. (英) KeywordList.Keyword: prion protein

  10. (英) KeywordList.Keyword: scrapie