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著作: [毛利 安宏]/Ueda Yoshihiro/Yamano Tomoyoshi/松本 穣/[常山 幸一]/Kinashi Tatsuo/[松本 満]/Mode of tolerance induction and requirement for Aire are governed by the cell types that express self-antigen and those that present antigen/[The Journal of Immunology]

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EID
337532
EOID
937800
Map
0
LastModified
2019年1月16日(水) 16:51:31
Operator
三木 ちひろ
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TRUE
Censor
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Owner
松本 満
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 毛利 安宏([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生命科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Ueda Yoshihiro
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Yamano Tomoyoshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Matsumoto Minoru / (日) 松本 穣 / (読) まつもと みのる
    役割 任意
    貢献度 任意
    学籍番号 推奨 ****
  5. 常山 幸一([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.疾患病理学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Kinashi Tatsuo
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. 松本 満([徳島大学.先端酵素学研究所.重点研究部門])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Mode of tolerance induction and requirement for Aire are governed by the cell types that express self-antigen and those that present antigen

副題 任意
要約 任意

(英) Aire controls the fate of autoreactive thymocytes (i.e., clonal deletion or development into regulatory T cells [Tregs]) through transcriptional control of the expression of tissue-restricted self-antigens (TRAs) from medullary thymic epithelial cells (mTECs) and bone marrow (BM)-derived cells. Although TRAs expressed by mTECs and BM-derived cells are suggested to complement each other to generate a full spectrum of TRAs, little is known about the relative contribution of TRAs from each component for establishment of self-tolerance. Furthermore, the precise role of Aire in specific types of Aire-expressing APCs remains elusive. We have approached these issues by generating two different types of transgenic mouse (Tg) model, which express a prefixed model self-antigen driven by the insulin promoter or the Aire promoter. In the insulin-promoter Tg model, mTECs alone were insufficient for clonal deletion, and BM-derived APCs were required for this action by utilizing Ag transferred from mTECs. In contrast, mTECs alone were able to induce Tregs, although at a much lower efficiency in the absence of BM-derived APCs. Importantly, lack of Aire in mTECs, but not in BM-derived APCs, impaired both clonal deletion and production of Tregs. In the Aire-promoter Tg model, both mTECs and BM-derived APCs could independently induce clonal deletion without Aire, and production of Tregs was impaired by the lack of Aire in mTECs, but not in BM-derived APCs. These results suggest that the fate of autoreactive thymocytes together with the requirement for Aire depend on the cell types that express self-antigens and the types of APCs involved in tolerance induction.

キーワード 推奨
  1. (英) Animals
  2. (英) Antigen Presentation
  3. (英) Antigen-Presenting Cells
  4. (英) Autoantigens
  5. (英) Clonal Deletion
  6. (英) Epithelial Cells
  7. (英) Female
  8. (英) Gene Expression Regulation
  9. (英) Gene Knock-In Techniques
  10. (英) Genes, Synthetic
  11. インスリン(insulin)
  12. (英) Male
  13. (英) Mice
  14. (英) Mice, Inbred C57BL
  15. ノックアウトマウス(knockout mice)
  16. (英) Mice, Transgenic
  17. (英) Ovalbumin
  18. (英) Promoter Regions, Genetic
  19. (英) Rats
  20. (英) Specific Pathogen-Free Organisms
  21. (英) T-Lymphocytes, Regulatory
  22. (英) Thymus Gland
  23. (英) Transcription Factors
  24. (英) Transgenes
発行所 推奨
誌名 必須 The Journal of Immunology([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)
ISSN 任意 0022-1767
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 199
必須 12
必須 3959 3971
都市 任意
年月日 必須 2017年 11月 3日
URL 任意
DOI 任意 10.4049/jimmunol.1700892    (→Scopusで検索)
PMID 任意 29101311    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意 2-s2.0-85038566360
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) PublicationType: Journal Article