著作: [早渕 康信]/Ono Akemi/Homma Yukako/[香美 祥二]/Assessment of pulmonary arterial compliance evaluated using harmonic oscillator kinematics./[Pulmonary Circulation]
(英) Assessment of pulmonary arterial compliance evaluated using harmonic oscillator kinematics.
(英) We hypothesized that K, a harmonic oscillator kinematics-derived spring constant parameter of the pulmonary artery pressure (PAP) profile, reflects PA compliance in pediatric patients. In this prospective study of 33 children (age range = 0.5-20 years) with various cardiac diseases, we assessed the novel parameter designated as Kcalculated using the pressure phase plane and the equation K = (dP/dt_max)/([Pmax - Pmin])/2), where dP/dt_max is the peak derivative of PAP, and Pmax - Pmin is the difference between the minimum and maximum PAP. PA compliance was also calculated using two conventional methods: systolic PA compliance (sPAC) was expressed as the stroke volume/Pmax - Pmin; and diastolic PA compliance (dPAC) was determined according to a two-element Windkessel model of PA diastolic pressure decay. In addition, data were recorded during abdominal compression to determine the influence of preload on K. A significant correlation was observed between Kand sPAC (r = 0.52, P = 0.0018), but not dPAC. Significant correlations were also seen with the time constant (τ) of diastolic PAP (r = -0.51, P = 0.0026) and the pulmonary vascular resistance index (r = -0.39, P = 0.0242). No significant difference in Kwas seen between before and after abdominal compression. Khad a higher intraclass correlation coefficient than other compliance and resistance parameters for both intra-observer and inter-observer variability (0.998 and 0.997, respectively). These results suggest that Kcan provide insight into the underlying mechanisms and facilitate the quantification of PA compliance.
|発行所||推奨||(英) SAGE Publishing|
Pulmonary Circulation(Pulmonary Vascular Research Institute (Canterbury England))
|年月日||必須||2017年 7月 1日|