著作: [早渕 康信]/Ono Akemi/Homma Yukako/[香美 祥二]/Assessment of pulmonary arterial compliance evaluated using harmonic oscillator kinematics./[Pulmonary Circulation]
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削除する| 種別 | 必須 | 学術論文(審査論文) | |||
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| 言語 | 必須 | 英語 | |||
| 招待 | 推奨 | ||||
| 審査 | 推奨 | Peer Review | |||
| カテゴリ | 推奨 | 研究 | |||
| 共著種別 | 推奨 | ||||
| 学究種別 | 推奨 | ||||
| 組織 | 推奨 | ||||
| 著者 | 必須 | ||||
| 題名 | 必須 |
(英) Assessment of pulmonary arterial compliance evaluated using harmonic oscillator kinematics. |
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| 副題 | 任意 | ||||
| 要約 | 任意 |
(英) We hypothesized that K, a harmonic oscillator kinematics-derived spring constant parameter of the pulmonary artery pressure (PAP) profile, reflects PA compliance in pediatric patients. In this prospective study of 33 children (age range = 0.5-20 years) with various cardiac diseases, we assessed the novel parameter designated as Kcalculated using the pressure phase plane and the equation K = (dP/dt_max)/([Pmax - Pmin])/2), where dP/dt_max is the peak derivative of PAP, and Pmax - Pmin is the difference between the minimum and maximum PAP. PA compliance was also calculated using two conventional methods: systolic PA compliance (sPAC) was expressed as the stroke volume/Pmax - Pmin; and diastolic PA compliance (dPAC) was determined according to a two-element Windkessel model of PA diastolic pressure decay. In addition, data were recorded during abdominal compression to determine the influence of preload on K. A significant correlation was observed between Kand sPAC (r = 0.52, P = 0.0018), but not dPAC. Significant correlations were also seen with the time constant (τ) of diastolic PAP (r = -0.51, P = 0.0026) and the pulmonary vascular resistance index (r = -0.39, P = 0.0242). No significant difference in Kwas seen between before and after abdominal compression. Khad a higher intraclass correlation coefficient than other compliance and resistance parameters for both intra-observer and inter-observer variability (0.998 and 0.997, respectively). These results suggest that Kcan provide insight into the underlying mechanisms and facilitate the quantification of PA compliance. |
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| キーワード | 推奨 | ||||
| 発行所 | 推奨 | (英) SAGE Publishing | |||
| 誌名 | 必須 |
Pulmonary Circulation(Pulmonary Vascular Research Institute (Canterbury England))
(pISSN: 2045-8932, eISSN: 2045-8940)
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| 巻 | 必須 | 7 | |||
| 号 | 必須 | 3 | |||
| 頁 | 必須 | 666 673 | |||
| 都市 | 任意 | ||||
| 年月日 | 必須 | 2017年 7月 1日 | |||
| URL | 任意 | ||||
| DOI | 任意 | 10.1177/2045893217714781 (→Scopusで検索) | |||
| PMID | 任意 | 28621582 (→Scopusで検索) | |||
| CRID | 任意 | ||||
| WOS | 任意 | ||||
| Scopus | 任意 | ||||
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| 指導教員 | 推奨 | ||||
| 備考 | 任意 |
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