著作: Tanaka K,/[佐田 政隆]/Roles of Perivascular Adipose Tissue in the Pathogenesis of Atherosclerosis./[Frontiers in Physiology]
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削除する| 種別 | 必須 | 学術論文(審査論文) | ||||||||||||||||||
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| 言語 | 必須 | 英語 | ||||||||||||||||||
| 招待 | 推奨 | |||||||||||||||||||
| 審査 | 推奨 | Peer Review | ||||||||||||||||||
| カテゴリ | 推奨 | 研究 | ||||||||||||||||||
| 共著種別 | 推奨 | 国内共著(徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない)) | ||||||||||||||||||
| 学究種別 | 推奨 | |||||||||||||||||||
| 組織 | 推奨 | |||||||||||||||||||
| 著者 | 必須 |
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| 題名 | 必須 |
(英) Roles of Perivascular Adipose Tissue in the Pathogenesis of Atherosclerosis. |
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| 副題 | 任意 | |||||||||||||||||||
| 要約 | 任意 |
(英) Traditionally, it is believed that white adipose tissues serve as energy storage, heat insulation, and mechanical cushion, whereas non-shivering thermogenesis occurs in brown adipose tissue. Recent evidence revealed that adipose tissue secretes many types of cytokines, called as adipocytokines, which modulate glucose metabolism, lipid profile, appetite, fibrinolysis, blood pressure, and inflammation. Most of the arteries are surrounded by perivascular adipose tissue (PVAT). PVAT has been thought to be simply a structurally supportive tissue for vasculature. However, recent studies showed that PVAT influences vasodilation and vasocontraction, suggesting that PVAT regulates vascular tone and diameter. Adipocytokines secreted from PVAT appear to have direct access to the adjacent arterial wall by diffusion or via vasa vasorum. In fact, PVAT around atherosclerotic lesions and mechanically-injured arteries displayed inflammatory cytokine profiles, suggesting that PVAT functions to promote vascular lesion formation. Many clinical studies revealed that increased accumulation of epicardial adipose tissue (EAT), which surrounds coronary arteries, is associated with coronary artery disease. In this review article, we will summarize recent findings about potential roles of PVAT in the pathogenesis of atherosclerosis, particularly focusing on a series of basic and clinical studies from our laboratory. |
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| キーワード | 推奨 | |||||||||||||||||||
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| 誌名 | 必須 |
Frontiers in Physiology(Frontiers Media S.A.)
(eISSN: 1664-042X)
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| 巻 | 必須 | 9 | ||||||||||||||||||
| 号 | 必須 | 3 | ||||||||||||||||||
| 頁 | 必須 | 3 3 | ||||||||||||||||||
| 都市 | 任意 | |||||||||||||||||||
| 年月日 | 必須 | 2018年 2月 13日 | ||||||||||||||||||
| URL | 任意 | |||||||||||||||||||
| DOI | 任意 | 10.3389/fphys.2018.00003 (→Scopusで検索) | ||||||||||||||||||
| PMID | 任意 | 29487532 (→Scopusで検索) | ||||||||||||||||||
| CRID | 任意 | |||||||||||||||||||
| WOS | 任意 | |||||||||||||||||||
| Scopus | 任意 | 2-s2.0-85041922780 | ||||||||||||||||||
| 評価値 | 任意 | |||||||||||||||||||
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| 指導教員 | 推奨 | |||||||||||||||||||
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