著作: [青田 桂子]/[山ノ井 朋子]/[可児 耕一]/[東 雅之]/Cepharanthine inhibits IFN--induced CXCL10 by suppressing the JAK2/STAT1 signal pathway in human salivary gland ductal cells/[Inflammation]
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削除する| 種別 | 必須 | 学術論文(審査論文) | |||
|---|---|---|---|---|---|
| 言語 | 必須 | 英語 | |||
| 招待 | 推奨 | ||||
| 審査 | 推奨 | ||||
| カテゴリ | 推奨 | ||||
| 共著種別 | 推奨 | ||||
| 学究種別 | 推奨 | ||||
| 組織 | 推奨 | ||||
| 著者 | 必須 | ||||
| 題名 | 必須 |
(英) Cepharanthine inhibits IFN--induced CXCL10 by suppressing the JAK2/STAT1 signal pathway in human salivary gland ductal cells |
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| 副題 | 任意 | ||||
| 要約 | 任意 |
(英) Cepharanthine, a biscolaurine alkaloid isolated from the plant Stephania cephalantha Hayata, has been reported to have potent anti-inflammatory properties. Here, we investigated the effects of cepharanthine on the expression of CXCL10 (a CXC chemokine induced by interferon-gamma [IFN-γ] that has been observed in a wide variety of chronic inflammatory disorders and autoimmune conditions) in IFN-γ-treated human salivary gland cell lines. We observed that IFN-γ-induced CXCL10 production in NS-SV-DC cells (a human salivary gland ductal cell line), but not in NS-SV-AC cells (a human salivary gland acinar cell line). Cepharanthine inhibited the IFN-γ-induced CXCL10 production in NS-SV-DC cells. A Western blot analysis showed that cepharanthine prevented the phosphorylation of JAK2 and STAT1, but did not interfere with the NF-κB pathway. Moreover, cepharanthine inhibited the IFN-γ-mediated chemotaxis of Jurkat T cells. These results suggest that cepharanthine suppresses IFN-γ-induced CXCL10 production via the inhibition of the JAK2/STAT1 signaling pathway in human salivary gland ductal cells. Our findings also indicate that cepharanthine could inhibit the chemotaxis of Jurkat T cells by reducing CXCL10 production. |
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| キーワード | 推奨 | ||||
| 発行所 | 推奨 | ||||
| 誌名 | 必須 |
Inflammation([Springer-Verlag])
(pISSN: 0360-3997, eISSN: 1573-2576)
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| 巻 | 必須 | 41 | |||
| 号 | 必須 | 1 | |||
| 頁 | 必須 | 50 58 | |||
| 都市 | 任意 | ||||
| 年月日 | 必須 | 2018年 2月 初日 | |||
| URL | 任意 | ||||
| DOI | 任意 | 10.1007/s10753-017-0662-x (→Scopusで検索) | |||
| PMID | 任意 | 28879548 (→Scopusで検索) | |||
| CRID | 任意 | ||||
| WOS | 任意 | ||||
| Scopus | 任意 | ||||
| 機関リポジトリ | 112922 | ||||
| 評価値 | 任意 | ||||
| 被引用数 | 任意 | ||||
| 指導教員 | 推奨 | ||||
| 備考 | 任意 |
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