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著作: Goto Kenichi/Ogawa Emiko/Shimizu Kaoruko/Makita Hironi/[鈴木 秀宣]/[河田 佳樹]/[仁木 登]/Nishimura Masaharu/Nakano Yasutaka/Relationship of annual change in bone mineral density with extent of emphysematous lesions and pulmonary function in patients with COPD/[International Journal of Chronic Obstructive Pulmonary Disease]

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EID
336455
EOID
949746
Map
0
LastModified
2019年7月13日(土) 16:50:47
Operator
鈴木 秀宣
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TRUE
Censor
0
Owner
仁木 登
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Goto Kenichi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Ogawa Emiko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Shimizu Kaoruko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Makita Hironi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 鈴木 秀宣([徳島大学.ポストLEDフォトニクス研究所]/[徳島大学.理工学部.理工学科.光システムコース.光情報システム講座])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 河田 佳樹([徳島大学.ポストLEDフォトニクス研究所]/[徳島大学.理工学部.理工学科.光システムコース.光情報システム講座])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. 仁木 登
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Nishimura Masaharu
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. (英) Nakano Yasutaka
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Relationship of annual change in bone mineral density with extent of emphysematous lesions and pulmonary function in patients with COPD

副題 任意
要約 任意

(英) Osteoporosis is a well-known comorbidity in COPD. It is associated with poor health status and prognosis. Although the exact pathomechanisms are unclear, osteoporosis is suggested to be either a comorbidity due to shared risk factors with COPD or a systematic effect of COPD with a cause-effect relationship. This study aimed to evaluate whether progression of osteoporosis is synchronized with that of COPD. Data from 103 patients with COPD included in the Hokkaido COPD cohort study were analyzed. Computed tomography (CT) attenuation values of thoracic vertebrae 4, 7, and 10 were measured using custom software, and the average value (average bone density; ABD) was calculated. The percentage of low attenuation volume (LAV%) for each patient was also calculated for evaluation of emphysematous lesions. Annual change in thoracic vertebral CT attenuation, which is strongly correlated with dual-energy X-ray absorptiometry-measured bone mineral density, was compared with that in FEV or emphysematous lesions. In the first CT data set, ABD was significantly correlated with age (=-0.331; =0.0006), body mass index (BMI; =0.246; =0.0136), St George's Respiratory Questionnaire (SGRQ) activity score (=-0.248; =0.0115), eosinophil count (=0.229; =0.0198), and LAV% (=-0.372; =0.0001). However, ABD was not associated with FEV. After adjustment for age, BMI, SGRQ activity score, and eosinophil count, no significant relationship was found between ABD and LAV%. Annual change in ABD was not associated with annual change in LAV% or FEV. Progression of osteoporosis and that of COPD are not directly related or synchronized with each other.

キーワード 推奨
  1. (英) Aged
  2. (英) Bone Density
  3. (英) Disease Progression
  4. (英) Female
  5. (英) Forced Expiratory Volume
  6. (英) Humans
  7. (英) Lung
  8. (英) Male
  9. (英) Middle Aged
  10. (英) Osteoporosis
  11. (英) Prognosis
  12. (英) Pulmonary Disease, Chronic Obstructive
  13. (英) Pulmonary Emphysema
  14. (英) Radiographic Image Interpretation, Computer-Assisted
  15. (英) Risk Factors
  16. (英) Thoracic Vertebrae
  17. (英) Time Factors
  18. (英) Tomography, X-Ray Computed
  19. (英) Vital Capacity
発行所 推奨
誌名 必須 International Journal of Chronic Obstructive Pulmonary Disease(DOVE Medical Press)
(pISSN: 1176-9106, eISSN: 1178-2005)
ISSN 任意 1178-2005
ISSN: 1176-9106 (pISSN: 1176-9106, eISSN: 1178-2005)
Title: International journal of chronic obstructive pulmonary disease
Title(ISO): Int J Chron Obstruct Pulmon Dis
Publisher: Dove Medical Press Ltd
 (NLM Catalog  (Scopus  (CrossRef  (CrossRef (Scopus information is found. [need login])
必須 13
必須
必須 639 644
都市 任意
年月日 必須 2018年 2月 20日
URL 任意
DOI 任意 10.2147/COPD.S153750    (→Scopusで検索)
PMID 任意 29503537    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.2147/COPD.S153750

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  4. (英) KeywordList.Keyword: FEV1.0

  5. (英) KeywordList.Keyword: automatic analysis

  6. (英) KeywordList.Keyword: low attenuation volume

  7. (英) KeywordList.Keyword: osteoporosis

  8. (英) KeywordList.Keyword: quantitative CT analysis

  9. (英) KeywordList.Keyword: systemic effect

  10. (英) CoiStatement: Disclosure The authors report no conflicts of interest in this work.