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著作: Ishihara Akinori/[沢津橋 俊]/Yamauchi Kiyoshi/Endocrine disrupting chemicals: interference of thyroid hormone binding to transthyretins and to thyroid hormone receptors./[Molecular and Cellular Endocrinology]

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EID
335621
EOID
935697
Map
0
LastModified
2018年12月7日(金) 12:00:34
Operator
大家 隆弘
Avail
TRUE
Censor
0
Owner
沢津橋 俊
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Ishihara Akinori
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 沢津橋 俊([徳島大学.先端酵素学研究所.技術開発支援部門])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Yamauchi Kiyoshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Endocrine disrupting chemicals: interference of thyroid hormone binding to transthyretins and to thyroid hormone receptors.
副題 任意
要約 任意

(英) We examined the effects of industrial, medical and agricultural chemicals on 3,5,3'-L-[125I]triiodothyronine ([125I]T(3)) binding to transthyretins (TTRs) and thyroid hormone receptors (TRs). Among the chemicals investigated diethylstilbestrol (DES) was the most powerful inhibitor of [125I]T(3) binding to chicken and bullfrog TTR (cTTR and bTTR). Inhibition of [125I]T(3) binding was more apparent in cTTR than bTTR. Scatchard analysis revealed DES, pentachlorophenol and ioxynil as competitive inhibitors of [125I]T(3) binding to cTTR and bTTR. However, cTTR's affinity for the three chemicals was higher than its affinity for T(3). A miticide dicofol (10(-10)-10(-7) M) activated [125I]T(3) binding to bTTR up to 170%. However, at 4x10(-5) M it inhibited [125I]T(3) binding by 83%. Dicofol's biphasic effect upon [125I]T(3) binding was not detected in TTRs from other species. DES and pentachlorophenol, in the presence of plasma, increased cellular uptake of [125I]T(3) in vitro, by displacing [125I]T(3) from its plasma binding sites. These chemicals did not, however, affect the association of cTTR with chicken retinol-binding protein. All chemicals investigated had little or no influence on [125I]T(3) binding to chicken TR (cTR) and bullfrog TR (bTR). Several endocrine disrupting chemicals that were tested interfered with T(3) binding to TTR rather than to TR. Binding of the endocrine disrupting chemicals to TTR may weaken their intrinsic effects on target cells by depressing their free concentrations in plasma. However, this may affect TH homeostasis in vivo by altering the free concentrations of plasma THs.
キーワード 推奨
  1. (英) Animals
  2. (英) Binding, Competitive
  3. (英) Carrier Proteins
  4. (英) Chickens
  5. (英) Endocrine System
  6. (英) Erythrocytes
  7. (英) Humans
  8. (英) Iodine Radioisotopes
  9. (英) Membrane Proteins
  10. (英) Organic Chemicals
  11. (英) Prealbumin
  12. (英) Protein Binding
  13. (英) Rana catesbeiana
  14. (英) Receptors, Thyroid Hormone
  15. (英) Salmon
  16. (英) Thyroid Hormones
  17. (英) Triiodothyronine
発行所 推奨
誌名 必須 Molecular and Cellular Endocrinology([Elsevier])
(pISSN: 0303-7207, eISSN: 1872-8057)
ISSN 任意 0303-7207
ISSN: 0303-7207 (pISSN: 0303-7207, eISSN: 1872-8057)
Title: Molecular and cellular endocrinology
Title(ISO): Mol Cell Endocrinol
Publisher: Elsevier BV
 (NLM Catalog)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
巻 必須 199
号 必須 1-2
頁 必須 105 117
都市 任意
年月日 必須 2003年 1月 31日
URL 任意
DOI 任意 10.1016/S0303-7207(02)00302-7    (→Scopusで検索)
PMID 任意 12581883    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意

  1. (英) PublicationType: Journal Article

  2. (英) PublicationType: Research Support, Non-U.S. Gov't