335614: Zhao Yue/Takeyama Ken-ichi/[沢津橋俊]/Ito Saya/Suzuki Eriko/Yamagata Kaoru/Tanabe Masahiko/Kimura Shuhei/Fujiyama Sally/Ueda Takashi/Murata Takuya/Matsukawa Hiroyuki/Shirode Yuko/Kouzmenko Alexander P/Li Feng/Tabata Testuya/Kato Shigeaki/Corepressive action of CBP on androgen receptor transactivation in pericentric heterochromatin in a Drosophila experimental model system./[Molecular and Cellular Biology]

著作: Zhao Yue/Takeyama Ken-ichi/[沢津橋俊]/Ito Saya/Suzuki Eriko/Yamagata Kaoru/Tanabe Masahiko/Kimura Shuhei/Fujiyama Sally/Ueda Takashi/Murata Takuya/Matsukawa Hiroyuki/Shirode Yuko/Kouzmenko Alexander P/Li Feng/Tabata Testuya/Kato Shigeaki/Corepressive action of CBP on androgen receptor transactivation in pericentric heterochromatin in a Drosophila experimental model system./[Molecular and Cellular Biology]

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EID: 335614
EOID: 882799
Map: 0
LastModified: 2018年1月6日(土) 15:01:05
Operator: 沢津橋俊
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Censor: 0
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種別

必須

学術論文(審査論文)

言語

必須

英語

招待

推奨

審査

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カテゴリ

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共著種別

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学究種別

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組織

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著者

必須

(英) Zhao Yue

役割任意

貢献度任意

学籍番号推奨
(英) Takeyama Ken-ichi

役割任意

貢献度任意

学籍番号推奨
沢津橋俊([徳島大学.先端酵素学研究所.技術開発支援部門])

役割任意

貢献度任意

学籍番号推奨
(英) Ito Saya

役割任意

貢献度任意

学籍番号推奨
(英) Suzuki Eriko

役割任意

貢献度任意

学籍番号推奨
(英) Yamagata Kaoru

役割任意

貢献度任意

学籍番号推奨
(英) Tanabe Masahiko

役割任意

貢献度任意

学籍番号推奨
(英) Kimura Shuhei

役割任意

貢献度任意

学籍番号推奨
(英) Fujiyama Sally

役割任意

貢献度任意

学籍番号推奨
(英) Ueda Takashi

役割任意

貢献度任意

学籍番号推奨
(英) Murata Takuya

役割任意

貢献度任意

学籍番号推奨
(英) Matsukawa Hiroyuki

役割任意

貢献度任意

学籍番号推奨
(英) Shirode Yuko

役割任意

貢献度任意

学籍番号推奨
(英) Kouzmenko Alexander P

役割任意

貢献度任意

学籍番号推奨
(英) Li Feng

役割任意

貢献度任意

学籍番号推奨
(英) Tabata Testuya

役割任意

貢献度任意

学籍番号推奨
(英) Kato Shigeaki

役割任意

貢献度任意

学籍番号推奨

題名

必須

(英) Corepressive action of CBP on androgen receptor transactivation in pericentric heterochromatin in a Drosophila experimental model system.

副題

任意

要約

任意

(英) Ligand-bound nuclear receptors (NR) activate transcription of the target genes. This activation is coupled with histone modifications and chromatin remodeling through the function of various coregulators. However, the nature of the dependence of a NR coregulator action on the presence of the chromatin environment at the target genes is unclear. To address this issue, we have developed a modified position effect variegation experimental model system that includes an androgen-dependent reporter transgene inserted into either a pericentric heterochromatin region or a euchromatic region of Drosophila chromosome. Human androgen receptor (AR) and its constitutively active truncation mutant (AR AF-1) were transcriptionally functional in both chromosomal regions. Predictably, the level of AR-induced transactivation was lower in the pericentric heterochromatin. In genetic screening for AR AF-1 coregulators, Drosophila CREB binding protein (dCBP) was found to corepress AR transactivation at the pericentric region whereas it led to coactivation in the euchromatic area. Mutations of Sir2 acetylation sites or deletion of the CBP acetyltransferase domain abrogated dCBP corepressive action for AR at heterochromatic areas in vivo. Such a CBP corepressor function for AR was observed in the transcriptionally silent promoter of an AR target gene in cultured mammalian cells. Thus, our findings suggest that the action of NR coregulators may depend on the state of chromatin at the target loci.

キーワード

推奨

(英) Acetylation
(英) Amino Acid Sequence
(英) Animals
(英) CREB-Binding Protein
(英) Catalytic Domain
(英) Cell Line, Tumor
(英) Chromosomal Position Effects
(英) Conserved Sequence
(英) Drosophila Proteins
(英) Drosophila melanogaster
(英) Euchromatin
(英) Heterochromatin
(英) Histone Deacetylases
(英) Histones
(英) Humans
(英) Lysine
(英) Methylation
(英) Models, Genetic
(英) Molecular Sequence Data
(英) Promoter Regions, Genetic
(英) Receptors, Androgen
(英) Repressor Proteins
(英) Sirtuins
(英) Transcriptional Activation

発行所

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誌名

必須

Molecular and Cellular Biology([アメリカ微生物学会])

(pISSN: 0270-7306, eISSN: 1098-5549)

ISSN	任意	1098-5549 ISSN: 0270-7306 (pISSN: 0270-7306, eISSN: 1098-5549) Title: Molecular and cellular biology Title(ISO): Mol Cell Biol Publisher: American Society for Microbiology (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

必須

号

必須

頁

必須

1017 1034

都市

任意

年月日

必須

2008年 12月 15日

URL

任意

DOI

任意

10.1128/MCB.02123-07 (→Scopusで検索)

PMID

任意

19075001 (→Scopusで検索)

CRID

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WOS

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Scopus

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評価値

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被引用数

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指導教員

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備考

任意

(英) PublicationType: Journal Article
(英) PublicationType: Research Support, Non-U.S. Gov't

徳島大学教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University