徳島大学 教育・研究者情報データベース(EDB)

1. 沢津橋 俊([徳島大学.先端酵素学研究所.技術開発支援部門])

   役割	任意
   貢献度	任意
   学籍番号	推奨

(英) [Bone and Nutrition. The vitamin D functions in osteoblasts and osteocytes].

(英) The active form of vitamin D, 1,25-dihydroxyvitamin D(3) (1,25 (OH) (2)D(3)), plays a key role in mineral and bone homeostasis. 1,25 (OH) (2)D(3), through binding to the vitamin D receptor (VDR), a member of the nuclear receptor superfamily, regulates the expression of many genes in osteoblasts and osteocytes. The VDR functions in a largely 1,25 (OH) (2)D(3)-controlled manner by interacting directly with vitamin D response elements located within regulatory regions that are linked to cell-specific target genes. However, the mechanism of VDR action on these bone cell types remains largely unknown. While the direct actions of 1,25 (OH) (2)D(3) on bone cells are complex and include both cell autonomous and paracrine mechanisms. In this review, we discuss how the VDR affects the transcriptional response of these cells and contribute to bone homeostasis.

1. (英) Animals
2. (英) Autocrine Communication
3. (英) Calcification, Physiologic
4. (英) Homeostasis
5. (英) Humans
6. (英) Mice
7. (英) Osteoblasts
8. (英) Osteocytes
9. (英) Paracrine Communication
10. (英) Protein Binding
11. (英) Receptors, Calcitriol
12. (英) Transcription Factors
13. (英) Vitamin D

1. (英) CliCa1507991997