著作: Nishimura-Danjobara Yumiko/Oyama Keisuke/[金丸 芳]/Takahashi Keiko/[横井川 久己男]/[小山 保夫]/N-(3-oxododecanoyl)-L-homoserine-lactone, a quorum sensing molecule, affects cellular content of nonprotein thiol content in rat lymphocytes: Its relation with intracellular Zn2+/[Chemico-Biological Interactions]
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削除する| 種別 | 必須 | 学術論文(審査論文) | |||
|---|---|---|---|---|---|
| 言語 | 必須 | 英語 | |||
| 招待 | 推奨 | ||||
| 審査 | 推奨 | Peer Review | |||
| カテゴリ | 推奨 | 研究 | |||
| 共著種別 | 推奨 | 学内共著(徳島大学内研究者との共同研究 (学外研究者を含まない)) | |||
| 学究種別 | 推奨 | ||||
| 組織 | 推奨 |
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| 著者 | 必須 | ||||
| 題名 | 必須 |
(英) N-(3-oxododecanoyl)-L-homoserine-lactone, a quorum sensing molecule, affects cellular content of nonprotein thiol content in rat lymphocytes: Its relation with intracellular Zn2+ |
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| 副題 | 任意 | ||||
| 要約 | 任意 |
(英) Cellular actions of N-(3-oxododecanoyl)-L-homoserine-lactone (ODHL), a quorum sensing molecule of bacteria, were studied on rat thymocytes using a flow cytometer with appropriate fluorescent dyes to elucidate the effects of ODHL on host cells. A bell-shaped concentration-response relation was observed in the ODHL-induced changes in cellular glutathione content ([GSH]i). ODHL concentration-dependently increased intracellular Zn2+ levels ([Zn2+]i) and cellular O2- content ([O2-]i). The bell-shaped relation induced by ODHL can be explained as follows: a low concentration of ODHL is expected to induce moderate oxidative stress that intracellularly releases Zn2+ by converting thiols to disulfides. A slight elevation of [Zn2+]i may increase the [GSH]i. On the other hand, it is likely that a high concentration of ODHL causes severe oxidative stress that further causes both the decrease in [GSH]i and the increase in [Zn2+]i. Excessive increase in [Zn2+]i may augment oxidative stress that further decreases the [GSH]i. Other notable actions induced by ODHL included the elevation of [Zn2+]i by Zn2+ influx and the increase in [GSH]i under Zn2+-free conditions. Therefore, it is suggested that ODHL elicits diverse actions on host cells. |
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| キーワード | 推奨 |
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| 発行所 | 推奨 | Elsevier(->組織[Elsevier Science]) | |||
| 誌名 | 必須 |
Chemico-Biological Interactions([Elsevier Science])
(pISSN: 0009-2797, eISSN: 1872-7786)
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| 巻 | 必須 | 280 | |||
| 号 | 必須 | --- | |||
| 頁 | 必須 | 28 32 | |||
| 都市 | 任意 | アムステルダム(Amsterdam/[オランダ王国]) | |||
| 年月日 | 必須 | 2018年 1月 25日 | |||
| URL | 任意 | http://www.sciencedirect.com/science/article/pii/S0009279717312711 | |||
| DOI | 任意 | 10.1016/j.cbi.2017.12.013 (→Scopusで検索) | |||
| PMID | 任意 | 29223568 (→Scopusで検索) | |||
| CRID | 任意 | ||||
| WOS | 任意 | ||||
| Scopus | 任意 | ||||
| 機関リポジトリ | 111976 | ||||
| 評価値 | 任意 | ||||
| 被引用数 | 任意 | ||||
| 指導教員 | 推奨 | ||||
| 備考 | 任意 |
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