徳島大学 教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

徳島大学ウェブサイトへのリンク

著作: Suresh S. Padmanaban/Venkatesh Thejaswini/[堤 理恵]/In silico analysis of polymorphisms in microRNAs that target genes affecting aerobic glycolysis./[Annals of Translational Medicine]

ヘルプを読む

「著作」(著作(著書,論文,レター,国際会議など))は,研究業績にかかる著作(著書,論文,レター,国際会議など)を登録するテーブルです. (この情報が属するテーブルの詳細な定義を見る)

  • 項目名の部分にマウスカーソルを置いて少し待つと,項目の簡単な説明がツールチップ表示されます.

この情報をEDB閲覧画面で開く

EID
332557
EOID
870423
Map
0
LastModified
2017年8月29日(火) 13:52:11
Operator
大家 隆弘
Avail
TRUE
Censor
0
Owner
堤 理恵
Read
継承
Write
継承
Delete
継承
種別 必須
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Suresh S. Padmanaban
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Venkatesh Thejaswini
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 堤 理恵([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.代謝栄養学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) In silico analysis of polymorphisms in microRNAs that target genes affecting aerobic glycolysis.

副題 任意
要約 任意

(英) Cancer cells preferentially metabolize glucose through aerobic glycolysis, an observation known as the Warburg effect. Recently, studies have deciphered the role of oncogenes and tumor suppressor genes in regulating the Warburg effect. Furthermore, mutations in glycolytic enzymes identified in various cancers highlight the importance of the Warburg effect at the molecular and cellular level. MicroRNAs (miRNAs) are non-coding RNAs that posttranscriptionally regulate gene expression and are dysregulated in the pathogenesis of various types of human cancers. Single nucleotide polymorphisms (SNPs) in miRNA genes may affect miRNA biogenesis, processing, function, and stability and provide additional complexity in the pathogenesis of cancer. Moreover, mutations in miRNA target sequences in target mRNAs can affect expression. In silico analysis and cataloguing polymorphisms in miRNA genes that target genes directly or indirectly controlling aerobic glycolysis was carried out using different publically available databases. miRNA SNP2.0 database revealed several SNPs in miR-126 and miR-25 in the upstream and downstream pre-miRNA flanking regions respectively should be inserted after flanking regions and miR-504 and miR-451 had the fewest. These miRNAs target genes that control aerobic glycolysis indirectly. SNPs in premiRNA genes were found in miR-96, miR-155, miR-25 and miR34a by miRNASNP. Dragon database of polymorphic regulation of miRNA genes (dPORE-miRNA) database revealed several SNPs that modify transcription factor binding sites (TFBS) or creating new TFBS in promoter regions of selected miRNA genes as analyzed by dPORE-miRNA. Our results raise the possibility that integration of SNP analysis in miRNA genes with studies of metabolic adaptations in cancer cells could provide greater understanding of oncogenic mechanisms.

キーワード 推奨
発行所 推奨
誌名 必須 Annals of Translational Medicine(Society for Translational Medicine)
(pISSN: 2305-5839, eISSN: 2305-5847)
ISSN 任意 2305-5839
ISSN: 2305-5839 (pISSN: 2305-5839, eISSN: 2305-5847)
Title: Annals of translational medicine
Title(ISO): Ann Transl Med
Publisher: AME Publishing Company
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 4
必須 4
必須 69 69
都市 任意
年月日 必須 2016年 2月 初日
URL 任意
DOI 任意 10.3978/j.issn.2305-5839.2016.01.35    (→Scopusで検索)
PMID 任意 27004216    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.3978/j.issn.2305-5839.2016.01.35

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) OtherID: PMC4779782

  4. (英) KeywordList.Keyword: MicroRNAs (miRNA)

  5. (英) KeywordList.Keyword: cancer

  6. (英) KeywordList.Keyword: single nucleotide polymorphism (SNP)