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著作: Suresh S. Padmanaban/Venkatesh Thejaswini/[堤 理恵]/Shetty Abhishek/Next-generation sequencing for endocrine cancers: Recent advances and challenges./[Tumour Biology]

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EID
332555
EOID
870248
Map
0
LastModified
2017年8月28日(月) 18:49:58
Operator
大家 隆弘
Avail
TRUE
Censor
0
Owner
堤 理恵
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種別 必須
言語 必須 英語
招待 推奨
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共著種別 推奨
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著者 必須
  1. (英) Suresh S. Padmanaban
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Venkatesh Thejaswini
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    学籍番号 推奨
  3. 堤 理恵([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.代謝栄養学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Shetty Abhishek
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Next-generation sequencing for endocrine cancers: Recent advances and challenges.

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(英) Contemporary molecular biology research tools have enriched numerous areas of biomedical research that address challenging diseases, including endocrine cancers (pituitary, thyroid, parathyroid, adrenal, testicular, ovarian, and neuroendocrine cancers). These tools have placed several intriguing clues before the scientific community. Endocrine cancers pose a major challenge in health care and research despite considerable attempts by researchers to understand their etiology. Microarray analyses have provided gene signatures from many cells, tissues, and organs that can differentiate healthy states from diseased ones, and even show patterns that correlate with stages of a disease. Microarray data can also elucidate the responses of endocrine tumors to therapeutic treatments. The rapid progress in next-generation sequencing methods has overcome many of the initial challenges of these technologies, and their advantages over microarray techniques have enabled them to emerge as valuable aids for clinical research applications (prognosis, identification of drug targets, etc.). A comprehensive review describing the recent advances in next-generation sequencing methods and their application in the evaluation of endocrine and endocrine-related cancers is lacking. The main purpose of this review is to illustrate the concepts that collectively constitute our current view of the possibilities offered by next-generation sequencing technological platforms, challenges to relevant applications, and perspectives on the future of clinical genetic testing of patients with endocrine tumors. We focus on recent discoveries in the use of next-generation sequencing methods for clinical diagnosis of endocrine tumors in patients and conclude with a discussion on persisting challenges and future objectives.

キーワード 推奨
  1. (英) Endocrine Gland Neoplasms
  2. (英) Genome, Human
  3. (英) High-Throughput Nucleotide Sequencing
  4. (英) Humans
  5. (英) Sequence Analysis, DNA
発行所 推奨
誌名 必須 Tumour Biology(International Society for Oncodevelopmental Biology and Medicine)
(pISSN: 1010-4283, eISSN: 1423-0380)
ISSN 任意 1423-0380
ISSN: 1010-4283 (pISSN: 1010-4283, eISSN: 1423-0380)
Title: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
Title(ISO): Tumour Biol
Publisher: SAGE Publications
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 39
必須 5
必須 1010428317698376 1010428317698376
都市 任意
年月日 必須 2017年 5月 初日
URL 任意
DOI 任意 10.1177/1010428317698376    (→Scopusで検索)
PMID 任意 28459368    (→Scopusで検索)
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備考 任意
  1. (英) Article.ELocationID: 10.1177/1010428317698376

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Review

  4. (英) KeywordList.Keyword: Next-generation sequencing

  5. (英) KeywordList.Keyword: endocrine cancer