332478: [今西正樹]/Yoichi Chiba/Noriko Tomita/Shinji Matsunaga/Toshitaka Nakagawa/Masaki Ueno/Kazuhiro Yamamoto/[玉置俊晃]/[冨田修平]/Hypoxia-Inducible Factor-1α in Smooth Muscle Cells Protects Against Aortic Aneurysms-Brief Report./[Arteriosclerosis, Thrombosis, and Vascular Biology]

著作: [今西正樹]/Yoichi Chiba/Noriko Tomita/Shinji Matsunaga/Toshitaka Nakagawa/Masaki Ueno/Kazuhiro Yamamoto/[玉置俊晃]/[冨田修平]/Hypoxia-Inducible Factor-1α in Smooth Muscle Cells Protects Against Aortic Aneurysms-Brief Report./[Arteriosclerosis, Thrombosis, and Vascular Biology]

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EID: 332478
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種別

必須

学術論文(審査論文)

言語

必須

英語

招待

推奨

審査

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カテゴリ

推奨

共著種別

推奨

学究種別

推奨

組織

推奨

著者

必須

今西正樹([徳島大学.大学院医歯薬学研究部.薬学域.先端薬学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品機能生化学])

役割任意

貢献度任意

学籍番号推奨
(英) Yoichi Chiba

役割任意

貢献度任意

学籍番号推奨
(英) Noriko Tomita

役割任意

貢献度任意

学籍番号推奨
(英) Shinji Matsunaga

役割任意

貢献度任意

学籍番号推奨
(英) Toshitaka Nakagawa

役割任意

貢献度任意

学籍番号推奨
(英) Masaki Ueno

役割任意

貢献度任意

学籍番号推奨
(英) Kazuhiro Yamamoto

役割任意

貢献度任意

学籍番号推奨
玉置俊晃

役割任意

貢献度任意

学籍番号推奨
冨田修平

役割任意

貢献度任意

学籍番号推奨

題名

必須

(英) Hypoxia-Inducible Factor-1α in Smooth Muscle Cells Protects Against Aortic Aneurysms-Brief Report.

副題

任意

要約

任意

(英) The purpose of this study was to determine the role of smooth muscle cell-derived hypoxia-inducible factor-1α (Hif-1α) in the pathogenesis of aortic aneurysms. Control mice and smooth muscle cell-specific hypoxia-inducible factor-1α-deficient mice were infused with β-aminopropionitrile for 2 weeks and angiotensin II for 6 weeks to induce aortic aneurysm formation. Mutant mice experienced increased levels of aneurysm formation of the thoracic or abdominal aorta with more severe elastin disruption, compared with control mice. Smooth muscle cell-specific hypoxia-inducible factor-1α deficiency did not affect matrix metalloproteinase-2 activity; however, the activity of lysyl oxidase and the levels of tropoelastin mRNA in the angiotensin II- and β-aminopropionitrile-treated aortae, associated with elastin fiber formation, were suppressed. Furthermore, we observed reduced volumes of mature cross-linked elastin in the thoracoabdominal aorta after treatment with angiotensin II and β-aminopropionitrile. Deficiency of smooth muscle cell-derived hypoxia-inducible factor-1α augments aortic aneurysms, accompanied by disruption of elastin fiber formation, but not changes of elastin fiber degradation.

キーワード

推奨

(英) Aminopropionitrile
(英) Angiotensin II
(英) Animals
(英) Aorta, Abdominal
(英) Aorta, Thoracic
(英) Aortic Aneurysm, Abdominal
(英) Aortic Aneurysm, Thoracic
(英) Cells, Cultured
(英) Dilatation, Pathologic
(英) Disease Models, Animal
(英) Elastic Tissue
(英) Genetic Predisposition to Disease
(英) Hypoxia-Inducible Factor 1, alpha Subunit
男性(male)
(英) Mice, Knockout
(英) Muscle, Smooth, Vascular
(英) Myocytes, Smooth Muscle
(英) Phenotype
(英) Protein-Lysine 6-Oxidase
(英) Tropoelastin
(英) Vascular Remodeling

発行所

推奨

誌名

必須

Arteriosclerosis, Thrombosis, and Vascular Biology([American Heart Association])

(pISSN: 1079-5642, eISSN: 1524-4636)

ISSN	任意	1524-4636 ISSN: 1079-5642 (pISSN: 1079-5642, eISSN: 1524-4636) Title: Arteriosclerosis, thrombosis, and vascular biology Title(ISO): Arterioscler Thromb Vasc Biol Publisher: American Heart Association (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

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号

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頁

必須

2158 2162

都市

任意

年月日

必須

2016年 8月 25日

URL

任意

DOI

任意

10.1161/ATVBAHA.116.307784 (→Scopusで検索)

PMID

任意

27562915 (→Scopusで検索)

CRID

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WOS

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Scopus

任意

2-s2.0-84983748456

評価値

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被引用数

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指導教員

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備考

任意

(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) KeywordList.Keyword: aneurysm
(英) KeywordList.Keyword: angiotensin II
(英) KeywordList.Keyword: elastin
(英) KeywordList.Keyword: extracellular matrix
(英) KeywordList.Keyword: hypoxia
(英) KeywordList.Keyword: smooth muscle
(英) KeywordList.Keyword: vascular remodeling

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著作: [今西正樹]/Yoichi Chiba/Noriko Tomita/Shinji Matsunaga/Toshitaka Nakagawa/Masaki Ueno/Kazuhiro Yamamoto/[玉置俊晃]/[冨田修平]/Hypoxia-Inducible Factor-1α in Smooth Muscle Cells Protects Against Aortic Aneurysms-Brief Report./[Arteriosclerosis, Thrombosis, and Vascular Biology]