徳島大学 教育・研究者情報データベース(EDB)

1. 宇山 直人

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2. 大塚 秀樹([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.放射線科学系.画像医学・核医学]/[徳島大学.医学部.保健学科.放射線技術科学専攻.診療放射線技術学講座])

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3. 新家 崇義([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])

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4. 音見 暢一([徳島大学.病院.中央診療施設等.放射線部]/[徳島大学.病院.診療科.放射線科.放射線診断科])

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5. 原田 雅史([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.放射線医学])

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6. 佐光 亘

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7. (英) Izumi Yuishin

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8. 梶 龍兒

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9. (英) Watanabe Yuya

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10. (英) Takashi Satoru

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11. (英) Kunikane Yamato

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(英) The utility of the combination of a SPECT study with [123I]-FP-CIT of dopamine transporters and [123I]-MIBG myocardial scintigraphy in differentiating Parkinson disease from other degenerative parkinsonian syndromes.

(英) Molecular imaging of nigrostriatal dopamine transporters (DAT) and sympathetic cardiac innervation with single-photon emission computed tomography (SPECT) are useful tools for differentiating idiopathic Parkinson disease (PD) from other degenerative parkinsonian syndromes (non-PD). Nevertheless, these modalities are often insufficient for achieving a definite diagnosis. The aims of this study were to evaluate the diagnostic accuracy of the combination of these tools. The SPECT radiotracers [I]-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)-nortropane (FP-CIT) and meta-[I]-iodobenzylguanidine (MIBG) were used to research presynaptic dopaminergic projections (DAT SPECT) and myocardial adrenergic innervation (MIBG scintigraphy), respectively. PD patients (n=15; age: 61.5±13.6 years) and non-PD patients (n=19; age: 62.6±14.2 years) who underwent both tests were enrolled in this study. Receiver-operating characteristic analyses were used to set the cutoff values of the specific binding ratio in DAT SPECT and the heart to mediastinum ratio in delayed scan in MIBG scintigraphy for differentiating PD from non-PD. We calculated the sensitivity, specificity, and test accuracy of the individual methods and also the combination of these two modalities. When DAT SPECT and MIBG scintigraphy were used individually, they showed mild accuracy in differentiating PD from non-PD (DAT, 67.6%; MIBG, 67.6%). The combination of the two approaches using cutoff values of less than 3.24 for the specific binding ratio and less than 2.745 for the delayed heart to mediastinum ratio enabled more accurate differentiation between PD and non-PD. The accuracy of these indices in distinguishing PD from non-PD was 79.4%. These results suggested that the combination of DAT SPECT and MIBG scintigraphy may improve the diagnostic accuracy in differentiating PD from non-PD.

1. (英) 3-Iodobenzylguanidine
2. (英) Adult
3. (英) Aged
4. (英) Aged, 80 and over
5. (英) Diagnosis, Differential
6. (英) Dopamine Plasma Membrane Transport Proteins
7. 女性(female)
8. (英) Humans
9. 男性(male)
10. (英) Middle Aged
11. (英) Myocardial Perfusion Imaging
12. パーキンソン病(Parkinson's disease)
13. (英) Parkinsonian Disorders
14. (英) ROC Curve
15. (英) Tomography, Emission-Computed, Single-Photon
16. (英) Tropanes

1. (英) Article.ELocationID: 10.1097/MNM.0000000000000674

2. (英) Article.PublicationTypeList.PublicationType: Journal Article