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著作: Masuki Shizue/[西田 憲生]/Hashimoto Shigenari/Morikawa Mayuko/Takasugi Satoshi/Nagata Masashi/Taniguchi Shun'ichiro/[六反 一仁]/Nose Hiroshi/Effects of milk product intake on thigh muscle strength and NFKB gene methylation during home-based interval walking training in older women: A randomized, controlled pilot study./[PLoS ONE]

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EID
331521
EOID
933012
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0
LastModified
2018年11月29日(木) 11:56:43
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西田 憲生
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Masuki Shizue
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 西田 憲生([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.社会医学系.医療教育学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Hashimoto Shigenari
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Morikawa Mayuko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Takasugi Satoshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Nagata Masashi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Taniguchi Shun'ichiro
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. 六反 一仁
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. (英) Nose Hiroshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Effects of milk product intake on thigh muscle strength and NFKB gene methylation during home-based interval walking training in older women: A randomized, controlled pilot study.

副題 任意
要約 任意

(英) Muscle atrophy with aging is closely associated with chronic systemic inflammation and lifestyle-related diseases. In the present study, we assessed whether post-exercise milk product intake during 5-month interval walking training (IWT) enhanced the increase in thigh muscle strength and ameliorated susceptibility to inflammation in older women. Subjects [n = 37, 66±5 (standard deviation) yrs] who had been performing IWT for >6 months participated in this study. They were randomly divided into the following 3 groups: IWT alone (CNT, n = 12), IWT + low-dose post-exercise milk product intake (LD, n = 12; 4 g protein and 3 g carbohydrate) or IWT + a 3-times higher dose of milk product intake than the LD group (HD, n = 13). They were instructed to repeat ≥5 sets of fast and slow walking for 3 min each at ≥70% and 40% peak aerobic capacity for walking, respectively, per day for ≥4 days/week. After IWT, thigh muscle strength increased in the HD group (8±2%) more than in the CNT group (-2±3%, P = 0.022), despite similar IWT achievements between the groups (P>0.15). Pyrosequencing analysis using whole blood showed that methylation of NFKB1 and NFKB2, master genes of inflammation, was enhanced in the HD group (29±7% and 44±11%, respectively) more than in the CNT group (-20±6% and -10±6%, respectively; P<0.001). Moreover, the genome-wide DNA methylation analysis showed that several inflammation-related genes were hyper-methylated in the HD group compared with that in the CNT group, suggesting greater pro-inflammatory cytokine gene suppression in the HD group. HD milk product intake after exercise produced a greater percent increase in thigh muscle strength and NFKB1 and NFKB2 gene methylation during IWT in physically active older women. UMIN-CTR No. UMIN000024544 and No. UMIN000024912.

キーワード 推奨
  1. (英) Age Factors
  2. (英) Aged
  3. (英) Animals
  4. (英) Blood Cells
  5. (英) CpG Islands
  6. (英) DNA Methylation
  7. (英) Dairy Products
  8. (英) Exercise
  9. (英) Female
  10. (英) Gene Expression Profiling
  11. (英) Genome-Wide Association Study
  12. (英) Humans
  13. (英) Middle Aged
  14. (英) Milk
  15. (英) Muscle Strength
  16. (英) NF-kappa B
  17. (英) Patient Compliance
  18. (英) Physical Fitness
  19. (英) Pilot Projects
  20. (英) Promoter Regions, Genetic
  21. (英) Signal Transduction
  22. (英) Thigh
  23. (英) Time Factors
  24. (英) Walking
発行所 推奨
誌名 必須 PLoS ONE(Public Library of Science)
(eISSN: 1932-6203)
ISSN 任意 1932-6203
ISSN: 1932-6203 (eISSN: 1932-6203)
Title: PloS one
Title(ISO): PLoS One
Publisher: PLOS
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 12
必須 5
必須 e0176757 e0176757
都市 任意
年月日 必須 2017年 5月 17日
URL 任意
DOI 任意 10.1371/journal.pone.0176757    (→Scopusで検索)
PMID 任意 28520754    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意
機関リポジトリ 112337
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1371/journal.pone.0176757

  2. (英) Article.PublicationTypeList.PublicationType: Clinical Trial

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) Article.PublicationTypeList.PublicationType: Randomized Controlled Trial