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著作: Ronca Shannon E/Smith Jeanon/[駒 貴明]/Miller Magda M/Yun Nadezhda/Dineley Kelly T/Paessler Slobodan/Mouse Model of Neurological Complications Resulting from Encephalitic Alphavirus Infection./[Frontiers in Microbiology]

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EID
331125
EOID
937187
Map
0
LastModified
2018年12月25日(火) 16:31:10
Operator
三木 ちひろ
Avail
TRUE
Censor
0
Owner
駒 貴明
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Ronca Shannon E
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Smith Jeanon
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    貢献度 任意
    学籍番号 推奨
  3. 駒 貴明([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.微生物病原学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Miller Magda M
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Yun Nadezhda
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Dineley Kelly T
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Paessler Slobodan
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Mouse Model of Neurological Complications Resulting from Encephalitic Alphavirus Infection.

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要約 任意

(英) Long-term neurological complications, termed sequelae, can result from viral encephalitis, which are not well understood. In human survivors, alphavirus encephalitis can cause severe neurobehavioral changes, in the most extreme cases, a schizophrenic-like syndrome. In the present study, we aimed to adapt an animal model of alphavirus infection survival to study the development of these long-term neurological complications. Upon low-dose infection of wild-type C57B/6 mice, asymptomatic and symptomatic groups were established and compared to mock-infected mice to measure general health and baseline neurological function, including the acoustic startle response and prepulse inhibition paradigm. Prepulse inhibition is a robust operational measure of sensorimotor gating, a fundamental form of information processing. Deficits in prepulse inhibition manifest as the inability to filter out extraneous sensory stimuli. Sensory gating is disrupted in schizophrenia and other mental disorders, as well as neurodegenerative diseases. Symptomatic mice developed deficits in prepulse inhibition that lasted through 6 months post infection; these deficits were absent in asymptomatic or mock-infected groups. Accompanying prepulse inhibition deficits, symptomatic animals exhibited thalamus damage as visualized with H&E staining, as well as increased GFAP expression in the posterior complex of the thalamus and dentate gyrus of the hippocampus. These histological changes and increased GFAP expression were absent in the asymptomatic and mock-infected animals, indicating that glial scarring could have contributed to the prepulse inhibition phenotype observed in the symptomatic animals. This model provides a tool to test mechanisms of and treatments for the neurological sequelae of viral encephalitis and begins to delineate potential explanations for the development of such sequelae post infection.

キーワード 推奨
発行所 推奨
誌名 必須 Frontiers in Microbiology(Frontiers Media S.A.)
(eISSN: 1664-302X)
ISSN 任意 1664-302X
ISSN: 1664-302X (eISSN: 1664-302X)
Title: Frontiers in microbiology
Title(ISO): Front Microbiol
Publisher: Frontiers Media S.A.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 8
必須 ---
必須 188 188
都市 任意
年月日 必須 2017年 2月 7日
URL 任意
DOI 任意 10.3389/fmicb.2017.00188    (→Scopusで検索)
PMID 任意 28223982    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意 2-s2.0-85014558857
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) PublicationType: Journal Article