徳島大学 教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

徳島大学ウェブサイトへのリンク

著作: Kato Tomoko/[藤野 裕道]/Oyama Satomi/Kawashima Tatsuo/Murayama Toshihiko/Indomethacin induces cellular morphological change and migration via epithelial-mesenchymal transition in A549 human lung cancer cells: a novel cyclooxygenase-inhibition-independent effect./[Biochemical Pharmacology]

ヘルプを読む

「著作」(著作(著書,論文,レター,国際会議など))は,研究業績にかかる著作(著書,論文,レター,国際会議など)を登録するテーブルです. (この情報が属するテーブルの詳細な定義を見る)

  • 項目名の部分にマウスカーソルを置いて少し待つと,項目の簡単な説明がツールチップ表示されます.

この情報をEDB閲覧画面で開く

EID
329436
EOID
865350
Map
0
LastModified
2017年8月17日(木) 16:35:07
Operator
藤野 裕道
Avail
TRUE
Censor
0
Owner
藤野 裕道
Read
継承
Write
継承
Delete
継承
種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Kato Tomoko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 藤野 裕道([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.生命薬理学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Oyama Satomi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Kawashima Tatsuo
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Murayama Toshihiko
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Indomethacin induces cellular morphological change and migration via epithelial-mesenchymal transition in A549 human lung cancer cells: a novel cyclooxygenase-inhibition-independent effect.

副題 任意
要約 任意

(英) Levels of cyclooxygenase (COX)-2 and its metabolite prostaglandin E(2) (PGE(2)) are frequently increased in colon cancer and other cancers including lung cancer. Non-steroidal anti-inflammatory drugs are considered to have chemo-preventive effects on these diseases by reducing the biosynthesis of PGE(2) via their inhibition of COX-2. Although the COX-2/PGE(2) pathway may directly impact on lung carcinogenesis, some population-based cohort studies of NSAIDs showed no significant protective effects. In this study, using human non-small-cell lung cancer A549 cells, we examined the effects of indomethacin, a potent NSAID, on the growth and motility of lung cancer cells. Besides inhibiting PGE(2) production and cellular growth, indomethacin caused drastic morphological changes with a loss of stress fibers in a time- and dose-dependent manner. Interestingly, the change in cellular shape caused by indomethacin was not seen when the cells were treated with aspirin or diclofenac, two other NSAIDs, despite the concentrations used being sufficient to inhibit PGE(2) production. The indomethacin-induced morphological changes in A549 cells were accompanied by a reduction in levels of the adhesion molecule E-cadherin and a component of basal lamina, collagen IV, as well as an increase in the activity of a collagenase, matrix metalloprotease-9. Furthermore, indomethacin-induced shape changes resulted in enhanced motility via regulation of peroxisome proliferator-activated receptor . The dual effects of indomethacin, inhibition of cellular growth and enhancement of migration, would explain, to some extent, the difficulty in using this NSAID for lung cancer therapy.

キーワード 推奨
  1. (英) Anticarcinogenic Agents
  2. (英) Aspirin
  3. (英) Cadherins
  4. (英) Cell Line, Tumor
  5. (英) Cell Movement
  6. (英) Cell Proliferation
  7. (英) Chromans
  8. (英) Collagen Type IV
  9. (英) Cyclooxygenase 2
  10. (英) Cyclooxygenase Inhibitors
  11. (英) Diclofenac
  12. (英) Dinoprostone
  13. (英) Epithelial-Mesenchymal Transition
  14. (英) Humans
  15. (英) Indomethacin
  16. (英) Lung Neoplasms
  17. (英) Matrix Metalloproteinase 9
  18. (英) PPAR gamma
  19. (英) Thiazolidinediones
発行所 推奨
誌名 必須 Biochemical Pharmacology([Elsevier Science])
(pISSN: 0006-2952, eISSN: 1873-2968)
ISSN 任意 1873-2968
ISSN: 0006-2952 (pISSN: 0006-2952, eISSN: 1873-2968)
Title: Biochemical pharmacology
Title(ISO): Biochem Pharmacol
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 82
必須 11
必須 1781 1791
都市 任意
年月日 必須 2011年 8月 4日
URL 任意
DOI 任意 10.1016/j.bcp.2011.07.096    (→Scopusで検索)
PMID 任意 21840302    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) PublicationType: Journal Article

  2. (英) PublicationType: Research Support, Non-U.S. Gov't