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著作: Yamane Satoshi/Kanno Toshio/Nakamura Hiroyuki/[藤野 裕道]/Murayama Toshihiko/Hydrogen sulfide-mediated regulation of contractility in the mouse ileum with electrical stimulation: roles of L-cysteine, cystathionine -synthase, and K+ channels./[European Journal of Pharmacology]

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EID
329421
EOID
906661
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0
LastModified
2018年5月18日(金) 18:05:26
Operator
藤野 裕道
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藤野 裕道
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Yamane Satoshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Kanno Toshio
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Nakamura Hiroyuki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 藤野 裕道([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.生命薬理学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Murayama Toshihiko
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Hydrogen sulfide-mediated regulation of contractility in the mouse ileum with electrical stimulation: roles of L-cysteine, cystathionine -synthase, and K+ channels.

副題 任意
要約 任意

(英) Hydrogen sulfide (H2S) is considered to be a signaling molecule. The precise mechanisms underlying H2S-related events, including the producing enzymes and target molecules in gastrointestinal tissues, have not been elucidated in detail. We herein examined the involvement of H2S in contractions induced by repeated electrical stimulations (ES). ES-induced contractions were neurotoxin-sensitive and increased by aminooxyacetic acid, an inhibitor of cystathionine -synthase (CBS) and cystathionine -lyase, but not by D,L-propargylglycine, a selective inhibitor of cystathionine -lyase, in an ES trial-dependent manner. ES-induced contractions were markedly decreased in the presence of L-cysteine. This response was inhibited by aminooxyacetic acid and an antioxidant, and accelerated by L-methionine, an activator of CBS. The existence of CBS was confirmed. NaHS transiently inhibited ES- and acetylcholine-induced contractions, and sustainably decreased basal tone for at least 20 min after its addition. The treatment with glibenclamide, an ATP-sensitive K+ channel blocker, reduced both the L-cysteine response and NaHS-induced inhibition of contractions. The NaHS-induced decrease in basal tone was inhibited by apamin, a small conductance Ca2+-activated K+ channel blocker. These results suggest that H2S may be endogenously produced via CBS in ES-activated enteric neurons, and regulates contractility via multiple K+ channels in the ileum.

キーワード 推奨
  1. (英) Acetylcholine
  2. (英) Aminooxyacetic Acid
  3. (英) Animals
  4. (英) Apamin
  5. (英) Cystathionine beta-Synthase
  6. (英) Cysteine
  7. (英) Electric Stimulation
  8. (英) Hydrogen Sulfide
  9. (英) Ileum
  10. (英) In Vitro Techniques
  11. (英) Male
  12. (英) Methionine
  13. (英) Mice
  14. (英) Muscle Contraction
  15. (英) Potassium Channel Blockers
  16. (英) Potassium Channels
発行所 推奨
誌名 必須 European Journal of Pharmacology([Elsevier])
(pISSN: 0014-2999, eISSN: 1879-0712)
ISSN 任意 1879-0712
ISSN: 0014-2999 (pISSN: 0014-2999, eISSN: 1879-0712)
Title: European journal of pharmacology
Title(ISO): Eur J Pharmacol
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 740
必須 ---
必須 112 120
都市 任意
年月日 必須 2014年 7月 5日
URL 任意
DOI 任意 10.1016/j.ejphar.2014.06.054    (→Scopusで検索)
PMID 任意 25008073    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) PublicationType: Journal Article

  2. (英) PublicationType: Research Support, Non-U.S. Gov't