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著作: Yamane Satoshi/Nomura Ryouya/Yanagihara Madoka/Nakamura Hiroyuki/[藤野 裕道]/Matsumoto Kenjiro/Horie Syunji/Murayama Toshihiko/L-Cysteine/D,L-homocysteine-regulated ileum motility via system L and B°(,+) transporter: Modification by inhibitors of hydrogen sulfide synthesis and dietary treatments./[European Journal of Pharmacology]

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EID
329418
EOID
906659
Map
0
LastModified
2018年5月18日(金) 18:04:10
Operator
藤野 裕道
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TRUE
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Owner
藤野 裕道
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Yamane Satoshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Nomura Ryouya
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Yanagihara Madoka
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Nakamura Hiroyuki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 藤野 裕道([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.生命薬理学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Matsumoto Kenjiro
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Horie Syunji
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Murayama Toshihiko
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) L-Cysteine/D,L-homocysteine-regulated ileum motility via system L and B°(,+) transporter: Modification by inhibitors of hydrogen sulfide synthesis and dietary treatments.

副題 任意
要約 任意

(英) Previous studies including ours demonstrated that L-cysteine treatments decreased motility in gastrointestinal tissues including the ileum via hydrogen sulfide (H2S), which is formed from sulfur-containing amino acids such as L-cysteine and L-homocysteine. However, the amino acid transport systems involved in L-cysteine/L-homocysteine-induced responses have not yet been elucidated in detail; therefore, we investigated these systems pharmacologically by measuring electrical stimulation (ES)-induced contractions with amino acids in mouse ileum preparations. The treatments with L-cysteine and D,L-homocysteine inhibited ES-induced contractions in ileum preparations from fasted mice, and these responses were decreased by the treatment with 2-aminobicyclo[2.2.1]heptane-2-carboxylate (BCH), an inhibitor of systems L and B°(,+). The results obtained using ileum preparations and a model cell line (PC12 cells) with various amino acids and BCH showed that not only L-cysteine, but also aminooxyacetic acid and D,L-propargylglycine, which act as H2S synthesis inhibitors, appeared to be taken up by these preparations/cells in L and B°(,+) system-dependent manners. The L-cysteine and D,L-homocysteine responses were delayed and abolished, respectively, in ileum preparations from fed mice. Our results suggested that the regulation of ileum motility by L-cysteine and D,L-homocysteine was dependent on BCH-sensitive systems, and varied depending on feeding in mice. Therefore, the effects of aminooxyacetic acid and D,L-propargylglycine on transport systems need to be considered in pharmacological analyses.

キーワード 推奨
  1. (英) Amino Acid Transport System y+L
  2. (英) Amino Acid Transport Systems, Neutral
  3. (英) Amino Acids, Cyclic
  4. (英) Animals
  5. (英) Cysteine
  6. (英) Diet
  7. (英) Eating
  8. (英) Electric Stimulation
  9. (英) Fasting
  10. (英) Gastrointestinal Motility
  11. (英) Homocysteine
  12. (英) Hydrogen Sulfide
  13. (英) Ileum
  14. (英) In Vitro Techniques
  15. (英) Male
  16. (英) Mice
  17. (英) PC12 Cells
  18. (英) Postprandial Period
  19. (英) Rats
  20. (英) Time Factors
発行所 推奨
誌名 必須 European Journal of Pharmacology([Elsevier])
(pISSN: 0014-2999, eISSN: 1879-0712)
ISSN 任意 1879-0712
ISSN: 0014-2999 (pISSN: 0014-2999, eISSN: 1879-0712)
Title: European journal of pharmacology
Title(ISO): Eur J Pharmacol
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 764
必須 ---
必須 471 479
都市 任意
年月日 必須 2015年 7月 19日
URL 任意
DOI 任意 10.1016/j.ejphar.2015.07.042    (→Scopusで検索)
PMID 任意 26201052    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) PublicationType: Journal Article