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著作: Terada Tomomasa/[漆原 真樹]/Saijo Takahiko/[中川 竜二]/[香美 祥二]/(Pro)renin and (pro)renin receptor expression during kidney development in neonates./[European Journal of Pediatrics]

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EID
328313
EOID
937181
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0
LastModified
2018年12月25日(火) 15:35:23
Operator
三木 ちひろ
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TRUE
Censor
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Owner
香美 祥二
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Terada Tomomasa
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 漆原 真樹([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.小児科学]/[徳島大学.病院.診療科.小児·周産·女性科.小児科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Saijo Takahiko
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 中川 竜二([徳島大学.病院.中央診療施設等.周産母子センター])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 香美 祥二([徳島大学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) (Pro)renin and (pro)renin receptor expression during kidney development in neonates.

副題 任意
要約 任意

(英) Although a recent study demonstrated that the (pro)renin receptor ((P)RR) was highly expressed in the developing kidney during the mouse embryonic development, the mechanism by which (P)RR supports renal development in humans is not fully understood. In this study, we examined the plasma levels of (pro)renin and soluble (P)RR (s(P)RR) in cord blood and neonates as well as (P)RR expression in human kidney tissues. Samples were collected from 57 preterm and 67 full-term human neonates. (Pro)renin and s(P)RR levels were measured using enzyme-linked immunosorbent assays. Additionally, we performed an immunohistochemical (IHC) analysis of kidney tissues from neonates and minor glomerular abnormalities in order to assess (P)RR expression in the kidney. Plasma (pro)renin and s(P)RR levels in cord blood were significantly higher in preterm neonates than in full-term neonates. Four weeks after birth, these differences were no longer evident for either plasma (pro)renin or s(P)RR levels between the two groups. Importantly, plasma (pro)renin and s(P)RR levels in cord blood were inversely correlated with gestational age. Furthermore, IHC indicated that renal expression levels of (P)RR in neonates were stronger than those in minor glomerular abnormalities. (P)RR may play a pivotal role in prenatal renal development in humans. What is Known: · Renal renin-angiotensin system (RAS) has several pathophysiologic functions not only in blood pressure regulation but also in pediatric renal disease. · Renal RAS activation plays a key role of renal development during gestation. What is New : · Plasma (pro)renin and soluble (pro)renin receptor (s(P)RR) levels in cord blood were significantly higher in preterm neonates than in full-term neonates. · Immunohistochemical analysis of kidney tissue indicated that renal expression levels of (P)RR in neonates were stronger than in minor glomerular abnormalities.

キーワード 推奨
  1. (英) Age Factors
  2. (英) Animals
  3. (英) Enzyme-Linked Immunosorbent Assay
  4. (英) Female
  5. (英) Fetal Blood
  6. (英) Gestational Age
  7. (英) Humans
  8. (英) Infant, Newborn
  9. (英) Infant, Premature
  10. (英) Kidney
  11. (英) Kidney Diseases
  12. (英) Male
  13. (英) Mice
  14. (英) Receptors, Cell Surface
  15. (英) Regression Analysis
  16. (英) Renin
  17. レニン·アンジオテンシンシステム(Renin-angiotensin System)
  18. (英) Term Birth
  19. (英) Vacuolar Proton-Translocating ATPases
発行所 推奨
誌名 必須 European Journal of Pediatrics(Belgian Pediatric Society/Swiss Pediatric Society)
(pISSN: 0340-6199, eISSN: 1432-1076)
ISSN 任意 1432-1076
ISSN: 0340-6199 (pISSN: 0340-6199, eISSN: 1432-1076)
Title: European journal of pediatrics
Title(ISO): Eur J Pediatr
Supplier: Springer Online Journal Archive
Publisher: Springer
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 176
必須 2
必須 183 189
都市 任意
年月日 必須 2017年 2月 初日
URL 任意
DOI 任意 10.1007/s00431-016-2820-9    (→Scopusで検索)
PMID 任意 27995362    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意 2-s2.0-85006434722
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1007/s00431-016-2820-9

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Observational Study

  4. (英) KeywordList.Keyword: Cord blood

  5. (英) KeywordList.Keyword: Enzyme-linked immunosorbent assay

  6. (英) KeywordList.Keyword: Gestational age

  7. (英) KeywordList.Keyword: Immunohistochemistry

  8. (英) KeywordList.Keyword: Renin-angiotensin