徳島大学 教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

徳島大学ウェブサイトへのリンク

著作: [岩佐 武]/[松崎 利也]/Tungalagsuvd Altankhuu/Munkhzaya Munkhsaikhan/Yiliyasi Maira/[加藤 剛志]/[桑原 章]/[苛原 稔]/Developmental changes in the hypothalamic mRNA expression levels of PACAP and its receptor PAC1 and their sensitivity to fasting in male and female rats./[International Journal of Developmental Neuroscience]

ヘルプを読む

「著作」(著作(著書,論文,レター,国際会議など))は,研究業績にかかる著作(著書,論文,レター,国際会議など)を登録するテーブルです. (この情報が属するテーブルの詳細な定義を見る)

  • 項目名の部分にマウスカーソルを置いて少し待つと,項目の簡単な説明がツールチップ表示されます.

この情報をEDB閲覧画面で開く

EID
328267
EOID
933112
Map
0
LastModified
2018年11月29日(木) 11:57:43
Operator
[ADMIN]
Avail
TRUE
Censor
0
Owner
苛原 稔
Read
継承
Write
継承
Delete
継承
種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 岩佐 武([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.産科婦人科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 松崎 利也
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Tungalagsuvd Altankhuu
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Munkhzaya Munkhsaikhan
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Yiliyasi Maira
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 加藤 剛志([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.産科婦人科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. 桑原 章
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. 苛原 稔([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.産科婦人科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Developmental changes in the hypothalamic mRNA expression levels of PACAP and its receptor PAC1 and their sensitivity to fasting in male and female rats.

副題 任意
要約 任意

(英) The actions and responses of hypothalamic appetite regulatory and factors change markedly during the neonatal to pre-pubertal period. Pituitary adenylate cyclase-activating polypeptide (PACAP) has been found to play pivotal roles in the regulation of metabolic and nutritional status through its specific receptor PAC1. PACAP/PAC1 have anorectic roles, and their functions are regulated by leptin in adulthood. In the present study, we showed that hypothalamic PACAP mRNA expression decreases during the neonatal to pre-pubertal period (from postnatal day 10-30) in both male and female rats. During this period, hypothalamic PACAP mRNA expression was not affected by 24h fasting in either sex, while the serum leptin levels (leptin is a positive regulator of hypothalamic PACAP expression in adulthood) of both sexes were decreased by fasting. On the other hand, hypothalamic PAC1 mRNA expression did not change during the neonatal to pre-pubertal period in either sex; however, its levels were consistently higher in males than in females. Hypothalamic PAC1 mRNA expression was decreased by 24h fasting in males, but no such changes were observed in females. These results indicate while hypothalamic PACAP expression is sensitive to a negative energy state and the serum leptin level in adulthood, no such relationships are seen in the pre-pubertal period. In addition, we speculate that differences in the gonadal steroidal milieu might induce sexual dimorphism in the basal hypothalamic PAC1 mRNA level and its response to fasting. The mechanisms responsible for and the physiological effects of such changes in hypothalamic PACAP and PAC1 expression during the developmental period remain to be clarified.

キーワード 推奨
  1. (英) Age Factors
  2. (英) Analysis of Variance
  3. (英) Animals
  4. (英) Animals, Newborn
  5. (英) Fasting
  6. (英) Female
  7. (英) Gene Expression Regulation, Developmental
  8. (英) Hypothalamus
  9. (英) Leptin
  10. (英) Male
  11. (英) Pituitary Adenylate Cyclase-Activating Polypeptide
  12. (英) Pregnancy
  13. (英) RNA, Messenger
  14. (英) Rats
  15. (英) Rats, Sprague-Dawley
  16. (英) Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I
  17. (英) Sex Characteristics
発行所 推奨
誌名 必須 International Journal of Developmental Neuroscience(International Society for Developmental Neuroscience)
(pISSN: 0736-5748, eISSN: 1873-474X)
ISSN 任意 1873-474X
ISSN: 0736-5748 (pISSN: 0736-5748, eISSN: 1873-474X)
Title: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
Title(ISO): Int J Dev Neurosci
Supplier: International Society for Development Neuroscience
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 52
必須
必須 33 37
都市 任意
年月日 必須 2016年 5月 12日
URL 任意
DOI 任意 10.1016/j.ijdevneu.2016.05.003    (→Scopusで検索)
PMID 任意 27181029    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
機関リポジトリ 112450
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1016/j.ijdevneu.2016.05.003

  2. (英) Article.ELocationID: S0736-5748(16)30049-1

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) KeywordList.Keyword: Hypothalamus

  5. (英) KeywordList.Keyword: Leptin

  6. (英) KeywordList.Keyword: PAC1

  7. (英) KeywordList.Keyword: PACAP