著作: Funakoshi Y/Harada M/Otsuka H/[森 健治]/[伊藤 弘道]/Iwanaga T/Default mode network abnormalities in children with autism spectrum disorder detected by resting-state functional magnetic resonance imaging./[The Journal of Medical Investigation : JMI]
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種別 | 必須 | 学術論文(紀要その他) | |||
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言語 | 必須 | 英語 | |||
招待 | 推奨 | ||||
審査 | 推奨 | ||||
カテゴリ | 推奨 | ||||
共著種別 | 推奨 | ||||
学究種別 | 推奨 | ||||
組織 | 推奨 | ||||
著者 | 必須 | ||||
題名 | 必須 |
(英) Default mode network abnormalities in children with autism spectrum disorder detected by resting-state functional magnetic resonance imaging. |
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副題 | 任意 | ||||
要約 | 任意 |
(英) The purpose of this study was to investigate changes in the functional connectivity of the default mode network (DMN) in normal aging and in children with autistic spectrum disorder (ASD) by using resting-state functional magnetic resonance imaging (rsfMRI) and independent component analysis. Thirty-one healthy controls (HC) in four age groups (1-3, 4-8, 20-29, and 50-59 years) and 14 childhood ASD cases (1-8 years of age) were examined by rsfMRI echo-planar imaging on a clinical 3-T MRI scanner. Imaging of all children (1-8 years) was conducted under sedation, while adults were scanned in the awake state with eyes closed. The regions of DMN functional connectivity in the bilateral inferior parietal lobule and posterior cingulate cortex were smaller in HC children than in HC adults, and smaller in the ASD group than in the HC children. It is possible to observe developmental and pathological changes in the DMN by rsfMRI. Reduced DMN functional connectivity in children may be a useful biomarker for ASD diagnosis. J. Med. Invest. 63: 204-208, August, 2016. |
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キーワード | 推奨 |
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発行所 | 推奨 | ||||
誌名 | 必須 |
The Journal of Medical Investigation : JMI([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
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巻 | 必須 | 63 | |||
号 | 必須 | 3-4 | |||
頁 | 必須 | 204 208 | |||
都市 | 任意 | ||||
年月日 | 必須 | 2016年 0月 初日 | |||
URL | 任意 | ||||
DOI | 任意 | 10.2152/jmi.63.204 (→Scopusで検索) | |||
PMID | 任意 | 27644559 (→Scopusで検索) | |||
CRID | 任意 | ||||
WOS | 任意 | ||||
Scopus | 任意 | ||||
機関リポジトリ | 111182 | ||||
評価値 | 任意 | ||||
被引用数 | 任意 | ||||
指導教員 | 推奨 | ||||
備考 | 任意 |
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