著作: Heni Susilowati/[村上 圭史]/[湯本 浩通]/[天羽 崇]/[平尾 功治]/[弘田 克彦]/[松尾 敬志]/[三宅 洋一郎]/Royal jelly inhibits Pseudomonas aeruginosa adherence and reduces excessive inflammatory responses in human epithelial cells/[BioMed Research International]
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種別 | 必須 | 学術論文(審査論文) | |||
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言語 | 必須 | 英語 | |||
招待 | 推奨 | ||||
審査 | 推奨 | ||||
カテゴリ | 推奨 | ||||
共著種別 | 推奨 | 国際共著(徳島大学内研究者と国外研究機関所属研究者との共同研究) | |||
学究種別 | 推奨 | ||||
組織 | 推奨 | ||||
著者 | 必須 | ||||
題名 | 必須 |
(英) Royal jelly inhibits Pseudomonas aeruginosa adherence and reduces excessive inflammatory responses in human epithelial cells |
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副題 | 任意 | ||||
要約 | 任意 |
(英) is a Gram-negative bacterium and causes respiratory infection especially in elderly patients. Royal jelly has been used worldwide as a traditional remedy and as a nutrient; however, the effect against is unclear. The aim of this study was to analyze antibacterial, antiadherent, and anti-inflammatory effects of royal jelly against . Wild-type strain PAO1 and clinical isolates of were used for antibacterial assay and antiadherent assay to abiotic surface and epithelial cells, which are pharynx (Detroit 562) and lung (NCI-H292) epithelial cells. In anti-inflammatory assay, epithelial cells were pretreated with royal jelly before bacterial exposure to investigate its inhibitory effect on interleukin (IL-8) and macrophage inflammatory protein-3/CCL20 overproduction. Although royal jelly did not have antibacterial activity at concentration of 50% w/v, antiadherent activity was confirmed on the abiotic surface and epithelial cells under concentration of 25%. Pretreatment with royal jelly significantly inhibited overproduction of IL-8 and CCL20 from both cells. These results demonstrated that royal jelly inhibits adherence and protects epithelial cells from excessive inflammatory responses against infection. Our findings suggested that royal jelly may be a useful supplement as complementary and alternative medicine for preventing respiratory infection caused by . |
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キーワード | 推奨 | ||||
発行所 | 推奨 | ||||
誌名 | 必須 |
BioMed Research International(Hindawi Pub. Co.)
(pISSN: 2314-6133, eISSN: 2314-6141)
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巻 | 必須 | 2017 | |||
号 | 必須 | --- | |||
頁 | 必須 | 3191752 3191752 | |||
都市 | 任意 | ||||
年月日 | 必須 | 2017年 9月 17日 | |||
URL | 任意 | ||||
DOI | 任意 | 10.1155/2017/3191752 (→Scopusで検索) | |||
PMID | 任意 | 29075644 (→Scopusで検索) | |||
CRID | 任意 | ||||
WOS | 任意 | ||||
Scopus | 任意 | 2-s2.0-85030761989 | |||
機関リポジトリ | 112385 | ||||
評価値 | 任意 | ||||
被引用数 | 任意 | ||||
指導教員 | 推奨 | ||||
備考 | 任意 |
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