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著作: Nagai T/[漆原 真樹]/[木下 ゆき子]/Jamba A/[近藤 秀治]/[香美 祥二]/Differential regulation of angiotensin II-induced extracellular regulated kiase-1/2 and -5 in progressive glomerulonephritis./[Nephrology]

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EID
327463
EOID
867137
Map
0
LastModified
2017年8月20日(日) 20:18:03
Operator
大家 隆弘
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Censor
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Owner
香美 祥二
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Nagai T
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 漆原 真樹([徳島大学.病院.診療科.小児·周産·女性科.小児科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 木下 ゆき子
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Jamba A
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 近藤 秀治
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. 香美 祥二([徳島大学.病院])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Differential regulation of angiotensin II-induced extracellular regulated kiase-1/2 and -5 in progressive glomerulonephritis.

副題 任意
要約 任意

(英) Extracellular signal regulated kinase (ERK)1/2 and ERK5 are key kinases of the signalling pathways involved in various cellular responses to kidney injury; however, the mechanistic links between those kinase and renin-angiotensin system (RAS) activations in glomerulonephritis (GN) have not been fully elucidated. In this study, we sought to clarify the potential roles of ERK1/2 and ERK5 via RAS activation in the pathogenesis of GN. A rat model of progressive GN was induced by anti-glomerular basement membrane (GBM) injection and the signal transduction pathway in angiotensin II (Ang II)-induced glomerular pathologic alterations were investigated in primary cultured mesangial cells (MCs). Rats developed typical cellular crescents in glomeruli on day 7 that progressed to severe fibrocellular crescents and glomerulosclerosis on day 28. Strong expression of phospho-ERK1/2 was observed on day 7 and phospho-ERK5 expression was markedly increased on day 28 of GN. An angiotensin II type 1 receptor blocker (ARB) suppressed those augmentations. Moreover, ARB treatment attenuated the increases in macrophage infiltration and PCNA-positive cells observed on day 7 in GN rats, as well as the increase in collagen type 1 expression on day 28. Consistently, MCs stimulated by Ang II showed significant increases in proliferation and the expression of MCP-1 and collagen type 1. Interestingly, while the ERK1/2 inhibitor PD98059 abolished the elevations in MCP-1 expression and cell proliferation, the ERK5 inhibitor BIX02189 abrogated the elevation in collagen type 1 expression. Altogether, these data suggest that ERK1/2 regulates acute inflammatory reactions, while ERK5 promotes the development of RAS-induced chronic glomerular fibrosis activation in GN.

キーワード 推奨
  1. (英) Angiotensin II
  2. (英) Angiotensin II Type 1 Receptor Blockers
  3. (英) Animals
  4. (英) Disease Models, Animal
  5. (英) Fibrosis
  6. (英) Glomerular Mesangium
  7. (英) Glomerulonephritis
  8. (英) Inflammation
  9. (英) Mitogen-Activated Protein Kinase 3
  10. (英) Rats
  11. (英) Renin-Angiotensin System
  12. (英) Signal Transduction
発行所 推奨
誌名 必須 Nephrology(Asian Pacific Society of Nephrology)
(pISSN: 1320-5358, eISSN: 1440-1797)
ISSN 任意 1440-1797
ISSN: 1320-5358 (pISSN: 1320-5358, eISSN: 1440-1797)
Title: Nephrology (Carlton, Vic.)
Title(ISO): Nephrology (Carlton)
Supplier: Asian Pacific Society of Nephrology
Publisher: Blackwell
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 21
必須 11
必須 950 958
都市 任意
年月日 必須 2016年 11月 初日
URL 任意
DOI 任意 10.1111/nep.12685    (→Scopusで検索)
PMID 任意 26624246    (→Scopusで検索)
NAID 任意
WOS 任意
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1111/nep.12685

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) KeywordList.Keyword: extracellular signal-regulated kinase

  4. (英) KeywordList.Keyword: fibrosis

  5. (英) KeywordList.Keyword: glomerulonephritis

  6. (英) KeywordList.Keyword: macrophage infiltration

  7. (英) KeywordList.Keyword: renin-angiotensin system