徳島大学 教育・研究者情報データベース(EDB)

1. (英) Park Dong Won

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2. (英) Egi Moritoki

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3. 西村 匡司

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4. (英) Chang Youjin

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5. (英) Suh Gee Young

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6. (英) Lim Chae Man

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7. (英) Kim Jae Yeol

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8. (英) Tada Keiichi

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9. (英) Matsuo Koichi

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10. (英) Takeda Shinhiro

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11. (英) Tsuruta Ryosuke

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12. (英) Yokoyama Takeshi

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13. (英) Kim Seon Ok

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14. (英) Koh Younsuck

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(英) The Association of Fever with Total Mechanical Ventilation Time in Critically Ill Patients.

(英) This research aims to investigate the impact of fever on total mechanical ventilation time (TVT) in critically ill patients. Subgroup analysis was conducted using a previous prospective, multicenter observational study. We included mechanically ventilated patients for more than 24 hours from 10 Korean and 15 Japanese intensive care units (ICU), and recorded maximal body temperature under the support of mechanical ventilation (MAX(MV)). To assess the independent association of MAX(MV) with TVT, we used propensity-matched analysis in a total of 769 survived patients with medical or surgical admission, separately. Together with multiple linear regression analysis to evaluate the association between the severity of fever and TVT, the effect of MAX(MV) on ventilator-free days was also observed by quantile regression analysis in all subjects including non-survivors. After propensity score matching, a MAX(MV) 37.5°C was significantly associated with longer mean TVT by 5.4 days in medical admission, and by 1.2 days in surgical admission, compared to those with MAX(MV) of 36.5°C to 37.4°C. In multivariate linear regression analysis, patients with three categories of fever (MAX(MV) of 37.5°C to 38.4°C, 38.5°C to 39.4°C, and 39.5°C) sustained a significantly longer duration of TVT than those with normal range of MAX(MV) in both categories of ICU admission. A significant association between MAX(MV) and mechanical ventilator-free days was also observed in all enrolled subjects. Fever may be a detrimental factor to prolong TVT in mechanically ventilated patients. These findings suggest that fever in mechanically ventilated patients might be associated with worse mechanical ventilation outcome.

1. (英) APACHE
2. (英) Aged
3. (英) Aged, 80 and over
4. (英) Body Temperature
5. (英) Critical Illness
6. (英) Female
7. (英) Fever
8. (英) Humans
9. (英) Intensive Care Units
10. (英) Japan
11. (英) Linear Models
12. (英) Male
13. (英) Middle Aged
14. (英) Propensity Score
15. (英) Prospective Studies
16. (英) Republic of Korea
17. (英) Respiration, Artificial
18. (英) Risk Factors
19. (英) Sepsis
20. (英) Time Factors

1. (英) PublicationType: Journal Article