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著作: Nagao Mizuho/Borres P. Magnus/[杉本 真弓]/Petersson Johan Carl/Nakayama Satoshi/Kuwabara Yu/Masuda Sawako/Dykiel Patrik/Fujisawa Takao/Sensitization to secretoglobin and lipocalins in a group of young children with risk of developing respiratory allergy./[Clinical and Molecular Allergy : CMA]

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EID
326786
EOID
863819
Map
0
LastModified
2017年8月14日(月) 15:30:17
Operator
大家 隆弘
Avail
TRUE
Censor
0
Owner
杉本 真弓
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Nagao Mizuho
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Borres P. Magnus
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 杉本 真弓([徳島大学.病院.診療科.小児·周産·女性科.小児科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Petersson Johan Carl
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Nakayama Satoshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Kuwabara Yu
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Masuda Sawako
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Dykiel Patrik
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. (英) Fujisawa Takao
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Sensitization to secretoglobin and lipocalins in a group of young children with risk of developing respiratory allergy.

副題 任意
要約 任意

(英) Multiple sensitizations in early age have been reported to be a risk for development of asthma. This study evaluates the emergence and evolution of IgE to aeroallergens among a cohort of children with physician-diagnosed atopic dermatitis and/or showing food allergy symptoms and to examine the relation to asthma development. Three-hundred and four children (median age 13.4 months at entry) with food allergy symptoms and/or atopic dermatitis without asthma at inclusion were analysed for IgE antibodies against food-, indoor- and outdoor-allergens and pet allergen components and correlated to the individuals' outcome on asthma inception. At 2 years of follow-up, physician-diagnosed asthma was 19.7% (n = 49) and asthma diagnosed any time was 24% (n = 67). History of persistent cough and asthma of father, combination of milk- and wheat-allergy symptoms and dual sensitization to house dust mite and Japanese cedar were independent risk factors for asthma. Sensitization to dog was the most prevalent inhalant allergen at entry. Asthma children had a higher proportion of sensitization to dog, cat and horse allergens at entry compared with non-asthma children. Being sensitized to both food, house dust mite and pet allergens was strongly associated with asthma (p = 0.0006). Component resolved diagnosis for dog and cat allergens showed that IgE antibodies to Can f 1 and Fel d 1 was common even at very young age. Early sensitization to inhalant allergens increases the risk of developing asthma as well as having milk and wheat allergy symptoms. Sensitization to dog, was common at an early age despite dog ownership. Sensitization to secretoglobin and lipocalins and less to serum albumins explained the pet sensitization.

キーワード 推奨
発行所 推奨
誌名 必須 Clinical and Molecular Allergy : CMA([BioMed Central Ltd.])
(eISSN: 1476-7961)
ISSN 任意 1476-7961
ISSN: 1476-7961 (eISSN: 1476-7961)
Title: Clinical and molecular allergy : CMA
Title(ISO): Clin Mol Allergy
Publisher: BioMed Central
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 15
必須
必須 4 4
都市 任意
年月日 必須 2017年 3月 3日
URL 任意
DOI 任意 10.1186/s12948-017-0061-8    (→Scopusで検索)
PMID 任意 28270741    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意
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被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1186/s12948-017-0061-8

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) KeywordList.Keyword: Allergy

  4. (英) KeywordList.Keyword: Asthma

  5. (英) KeywordList.Keyword: Children

  6. (英) KeywordList.Keyword: Component resolved diagnosis

  7. (英) KeywordList.Keyword: Food allergy

  8. (英) KeywordList.Keyword: Lipocalin

  9. (英) KeywordList.Keyword: Molecular allergy diagnostics

  10. (英) KeywordList.Keyword: Pet allergen components

  11. (英) KeywordList.Keyword: Secretoglobin

  12. (英) KeywordList.Keyword: Sensitization