徳島大学 教育・研究者情報データベース(EDB)

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著作: Kwon H. Deborah/[楠瀬 賢也]/Obuchowski A. Nancy/Cavalcante L. João/Popovic B. Zoran/Thomas D. James/Desai Y. Milind/Flamm D. Scott/Griffin P. Brian/Predictors and Prognostic Impact of Progressive Ischemic Mitral Regurgitation in Patients With Advanced Ischemic Cardiomyopathy: A Multimodality Study./[Circulation. Cardiovascular Imaging]

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EID
326337
EOID
859344
Map
0
LastModified
2017年7月26日(水) 15:56:11
Operator
三木 ちひろ
Avail
TRUE
Censor
承認済
Owner
楠瀬 賢也
Read
継承
Write
継承
Delete
継承
種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Kwon H. Deborah
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 楠瀬 賢也
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Obuchowski A. Nancy
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Cavalcante L. João
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Popovic B. Zoran
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Thomas D. James
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Desai Y. Milind
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Flamm D. Scott
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. (英) Griffin P. Brian
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Predictors and Prognostic Impact of Progressive Ischemic Mitral Regurgitation in Patients With Advanced Ischemic Cardiomyopathy: A Multimodality Study.

副題 任意
要約 任意

(英) Ischemic mitral regurgitation (IMR) is associated with poor outcomes. It is unknown what factors contribute to progression of IMR and how progressive IMR affects outcomes. We sought to determine imaging predictors of IMR progression and to determine if progressive IMR is an independent predictor of survival in patients with advanced ischemic cardiomyopathy. Consecutive advanced ischemic cardiomyopathy patients who underwent cardiac magnetic resonance and echocardiograms at baseline with echocardiographic follow-up were studied. Cardiac magnetic resonance was used to assess left ventricular volumes, infarct size, and mitral valve geometry. The effective regurgitant orifice area (EROA) was calculated from the proximal isovelocity surface area by echocardiography. Repeated measures mixed effects and Cox proportional hazards regression models were built to identify predictors of IMR progression and survival. We evaluated 336 patients (age, 62±11 years) over a median follow-up time of 54 months: 154 patients were subsequently revascularized, and 182 patients were medically treated. Ninety-eight patients (29%) demonstrated an increase in EROA values of ≥0.1 cm(2). There were 87 adverse events (death or transplant). On multivariable analysis, infarct size (P<0.001), progression in IMR (P=0.008), age (P=0.003), and baseline EROA (P=0.010) were independently associated with adverse events. Independent predictors of IMR progression were as follows: baseline EROA (P<0.001), left ventricular end-systolic volume index (P=0.014), and total scar (P=0.036). IMR frequently increases in severity, and progression is independently associated with adverse left ventricular remodeling and infarct size, as assessed by cardiac magnetic resonance. Furthermore, IMR progression is a powerful independent predictor of adverse events, even after controlling for the severity of IMR at baseline.

キーワード 推奨
  1. (英) Aged
  2. (英) Cardiomyopathies
  3. (英) Chi-Square Distribution
  4. (英) Coronary Stenosis
  5. (英) Disease Progression
  6. (英) Echocardiography
  7. (英) Female
  8. (英) Humans
  9. (英) Image Interpretation, Computer-Assisted
  10. (英) Magnetic Resonance Imaging, Cine
  11. (英) Male
  12. (英) Middle Aged
  13. (英) Mitral Valve Insufficiency
  14. マルチモーダルイメージング(multimodal imaging)
  15. (英) Multivariate Analysis
  16. (英) Myocardial Infarction
  17. 心筋(myocardium)
  18. (英) Observer Variation
  19. (英) Predictive Value of Tests
  20. (英) Prognosis
  21. (英) Proportional Hazards Models
  22. (英) Reproducibility of Results
  23. (英) Retrospective Studies
  24. (英) Risk Factors
  25. (英) Severity of Illness Index
  26. (英) Stroke Volume
  27. (英) Time Factors
  28. (英) Ventricular Function, Left
  29. (英) Ventricular Remodeling
発行所 推奨
誌名 必須 Circulation. Cardiovascular Imaging([American Heart Association])
(pISSN: 1941-9651, eISSN: 1942-0080)
ISSN 任意 1942-0080
ISSN: 1941-9651 (pISSN: 1941-9651, eISSN: 1942-0080)
Title: Circulation. Cardiovascular imaging
Title(ISO): Circ Cardiovasc Imaging
Publisher: American Heart Association
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 9
必須 7
必須
都市 任意
年月日 必須 2016年 7月 初日
URL 任意
DOI 任意 10.1161/CIRCIMAGING.115.004577    (→Scopusで検索)
PMID 任意 27406842    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意 2-s2.0-84978971718
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1161/CIRCIMAGING.115.004577

  2. (英) Article.ELocationID: e004577

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) Article.PublicationTypeList.PublicationType: Observational Study

  5. (英) KeywordList.Keyword: echocardiography

  6. (英) KeywordList.Keyword: magnetic resonance imaging

  7. (英) KeywordList.Keyword: mitral valve

  8. (英) KeywordList.Keyword: myocardial infarction