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著作: [島袋 充生]/Tanaka Atsushi/[佐田 政隆]/Dai Kazuoki/Sibata Yoshisato/Inoue Yohei/Ikenaga Hiroki/Kishimoto Shinji/Ogasawara Kozue/Takashima Akira/Niki Toshiyuki/Arasaki Osamu/Oshiro Koichi/Mori Yutaka/Ishihara Masaharu/Nobe Koichi/α-Glucosidase inhibitor miglitol attenuates glucose fluctuation, heart rate variability and sympathetic activity in patients with type 2 diabetes and acute coronary syndrome: a multicenter randomized controlled (MACS) study./[Cardiovascular Diabetology]

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EID
325813
EOID
937592
Map
0
LastModified
2019年1月9日(水) 15:02:34
Operator
三木 ちひろ
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TRUE
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Owner
佐田 政隆
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 島袋 充生
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Tanaka Atsushi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 佐田 政隆([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Dai Kazuoki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. (英) Sibata Yoshisato
    役割 任意
    貢献度 任意
    学籍番号 推奨
  6. (英) Inoue Yohei
    役割 任意
    貢献度 任意
    学籍番号 推奨
  7. (英) Ikenaga Hiroki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  8. (英) Kishimoto Shinji
    役割 任意
    貢献度 任意
    学籍番号 推奨
  9. (英) Ogasawara Kozue
    役割 任意
    貢献度 任意
    学籍番号 推奨
  10. (英) Takashima Akira
    役割 任意
    貢献度 任意
    学籍番号 推奨
  11. (英) Niki Toshiyuki
    役割 任意
    貢献度 任意
    学籍番号 推奨
  12. (英) Arasaki Osamu
    役割 任意
    貢献度 任意
    学籍番号 推奨
  13. (英) Oshiro Koichi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  14. (英) Mori Yutaka
    役割 任意
    貢献度 任意
    学籍番号 推奨
  15. (英) Ishihara Masaharu
    役割 任意
    貢献度 任意
    学籍番号 推奨
  16. (英) Nobe Koichi
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) α-Glucosidase inhibitor miglitol attenuates glucose fluctuation, heart rate variability and sympathetic activity in patients with type 2 diabetes and acute coronary syndrome: a multicenter randomized controlled (MACS) study.

副題 任意
要約 任意

(英) Little is known about clinical associations between glucose fluctuations including hypoglycemia, heart rate variability (HRV), and the activity of the sympathetic nervous system (SNS) in patients with acute phase of acute coronary syndrome (ACS). This pilot study aimed to evaluate the short-term effects of glucose fluctuations on HRV and SNS activity in type 2 diabetes mellitus (T2DM) patients with recent ACS. We also examined the effect of suppressing glucose fluctuations with miglitol on these variables. This prospective, randomized, open-label, blinded-endpoint, multicenter, parallel-group comparative study included 39 T2DM patients with recent ACS, who were randomly assigned to either a miglitol group (n = 19) or a control group (n = 20). After initial 24-h Holter electrocardiogram (ECG) (Day 1), miglitol was commenced and another 24-h Holter ECG (Day 2) was recorded. In addition, continuous glucose monitoring (CGM) was performed throughout the Holter ECG. Although frequent episodes of subclinical hypoglycemia (≤4.44 mmo/L) during CGM were observed on Day 1 in the both groups (35% of patients in the control group and 31% in the miglitol group), glucose fluctuations were decreased and the minimum glucose level was increased with substantial reduction in the episodes of subclinical hypoglycemia to 7.7% in the miglitol group on Day 2. Holter ECG showed that the mean and maximum heart rate and mean LF/HF were increased on Day 2 in the control group, and these increases were attenuated by miglitol. When divided 24-h time periods into day-time (0700-1800 h), night-time (1800-0000 h), and bed-time (0000-0700 h), we found increased SNS activity during day-time, increased maximum heart rate during night-time, and glucose fluctuations during bed-time, which were attenuated by miglitol treatment. In T2DM patients with recent ACS, glucose fluctuations with subclinical hypoglycemia were associated with alterations of HRV and SNS activity, which were mitigated by miglitol, suggesting that these pathological relationships may be a residual therapeutic target in such patients. Trial registration Unique Trial Number, UMIN000005874 ( https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000006929 ).

キーワード 推奨
  1. (英) 1-Deoxynojirimycin
  2. (英) Acute Coronary Syndrome
  3. (英) Adult
  4. (英) Aged
  5. (英) Blood Glucose
  6. (英) Diabetes Mellitus, Type 2
  7. (英) Female
  8. グルコース(glucose)
  9. (英) Glycoside Hydrolase Inhibitors
  10. (英) Heart Rate
  11. (英) Humans
  12. (英) Hypoglycemic Agents
  13. (英) Male
  14. (英) Middle Aged
  15. (英) Treatment Outcome
発行所 推奨
誌名 必須 Cardiovascular Diabetology([BioMed Central Ltd.])
(eISSN: 1475-2840)
ISSN 任意 1475-2840
ISSN: 1475-2840 (eISSN: 1475-2840)
Title: Cardiovascular diabetology
Title(ISO): Cardiovasc Diabetol
Publisher: BioMed Central
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 16
必須 1
必須 86 86
都市 任意
年月日 必須 2017年 7月 6日
URL 任意
DOI 任意 10.1186/s12933-017-0571-1    (→Scopusで検索)
PMID 任意 28683829    (→Scopusで検索)
CRID 任意
WOS 任意
Scopus 任意 2-s2.0-85022075532
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.ELocationID: 10.1186/s12933-017-0571-1

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Multicenter Study

  4. (英) Article.PublicationTypeList.PublicationType: Randomized Controlled Trial

  5. (英) KeywordList.Keyword: Acute coronary syndrome

  6. (英) KeywordList.Keyword: Glucose fluctuation

  7. (英) KeywordList.Keyword: Heart rate variability

  8. (英) KeywordList.Keyword: Hypoglycemia

  9. (英) KeywordList.Keyword: Miglitol

  10. (英) KeywordList.Keyword: Sympathetic nervous system activity

  11. (英) KeywordList.Keyword: Type 2 diabetes